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Case Reports
. 2015 Oct 24;1(6):371-4.
doi: 10.1016/j.jdcr.2015.09.008. eCollection 2015 Nov.

Rat-bite fever: An uncommon cause of fever and rash in a 9-year-old patient

Allen P Miraflor  1 , Ladan Davallow Ghajar  2 , Sathyaseelan Subramaniam  3 , Francine B de Abreu  1 , Mari Paz Castanedo-Tardan  4 , Faramarz H Samie  4 , Julianne Anderson Mann  4 , Alison Volpe Holmes  2 , Gregory J Tsongalis  1 , Shaofeng Yan  1
Affiliations
Case Reports

Rat-bite fever: An uncommon cause of fever and rash in a 9-year-old patient

Allen P Miraflor et al. JAAD Case Rep. .
No abstract available

Keywords: PCR, polymerase chain reaction; RBF, rat-bite fever; Streptobacillus moniliformis; bp, base pair; maculopapular rash; rat-bite fever.

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Figures

Fig 1
Fig 1
A, Erythematous papules on the abdomen. B, Purpuric pustules on the sole of the left foot. C, Pustules on erythematous bases on the right dorsal hand.
Fig 2
Fig 2
Histologic changes of the skin biopsy. A, Focal epidermal necrosis, dense superficial and deep perivascular inflammatory infiltrate. B, Dense perivascular neutrophilic infiltrate with fibrinoid change of the vessel wall, consistent with leukocytoclastic vasculitis. C, Gram-negative filamentous organisms identified within a small-sized blood vessel. (A, Hematoxylin-eosin stain; original magnification: ×40; B, Hematoxylin-eosin stain; original magnification: ×200; C, Gram stain; original magnification: ×1000.)
Fig 3
Fig 3
Molecular analysis of the undigested and digested PCR products. Blue arrow and blue a represent the undigested PCR amplicon (296 bp). Red arrows and red b, c, and d represent the digested PCR amplicon (72 bp, 93 bp, 130 bp, respectively). A, Agarose gel image containing negative control (1-2) and patient sample (3-4). Wells 1 and 3 represent the undigested PCR amplicon, and wells 2 and 4 represent the digested amplicon. B, Automated electrophoresis image (Experion) shows the undigested PCR amplicon (well 1), and the digested PCR amplicon (well 2).
See this image and copyright information in PMC

References

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    1. Boot R., Oosterhuis A., Thuis H.C. PCR for the detection of Streptobacillus moniliformis. Lab Anim. 2002;36:200–208. - PubMed

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