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. 2016 Nov;83(11):1353-1355.
doi: 10.1007/s12098-016-2096-0. Epub 2016 Apr 7.

GeneXpert for Diagnosis of Tubercular Meningitis

Rakesh Bhatia  1 , Rajeshwar Dayal  1 , Shishir Jindal  1 , Dipti Agarwal  2   3 , Ankur Goyal  4
Affiliations

GeneXpert for Diagnosis of Tubercular Meningitis

Rakesh Bhatia et al. Indian J Pediatr. 2016 Nov.

Abstract

Diagnosis of tubercular meningitis (TBM) is difficult in children. The GeneXpert MTB/RIF assay has been recommended by WHO in 2013 to be used in children and in extra pulmonary clinical specimens. The present study was designed to assess the diagnostic utility of GeneXpert in detecting Mycobacterium tuberculosis in cerebrospinal fluid (CSF) in TBM cases and to compare the results with liquid culture BACTEC 460. Thirty four subjects <15 y were diagnosed as TBM based on clinical, CSF and imaging details. Sensitivity of GeneXpert in CSF was 38.24 % as compared to Bactec culture which was only 14.71 % (p 0.0279). To conclude, GeneXpert MTB/RIF test is able to rapidly confirm diagnosis of TBM with higher sensitivity as compared to conventional methods and liquid culture.

Keywords: BACTEC; Cerebrospinal fluid; Diagnosis; GeneXpert; Tubercular meningitis.

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