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Review
. 2016 May;31(3):201-15.
doi: 10.1152/physiol.00038.2015.

Calcium, Reactive Oxygen Species, and Synaptic Plasticity

Cecilia Hidalgo  1 , Alejandra Arias-Cavieres  2
Affiliations
Free article
Review

Calcium, Reactive Oxygen Species, and Synaptic Plasticity

Cecilia Hidalgo et al. Physiology (Bethesda). 2016 May.
Free article

Abstract

In this review article, we address how activity-dependent Ca(2+)signaling is crucial for hippocampal synaptic/structural plasticity and discuss how changes in neuronal oxidative state affect Ca(2+)signaling and synaptic plasticity. We also analyze current evidence indicating that oxidative stress and abnormal Ca(2+)signaling contribute to age-related synaptic plasticity deterioration.

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