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Review
. 2016 Apr 5:13:12.
doi: 10.1186/s12979-016-0066-z. eCollection 2016.

Human longevity: Genetics or Lifestyle? It takes two to tango

Giuseppe Passarino  1 , Francesco De Rango  1 , Alberto Montesanto  1
Affiliations
Review

Human longevity: Genetics or Lifestyle? It takes two to tango

Giuseppe Passarino et al. Immun Ageing. .

Abstract

Healthy aging and longevity in humans are modulated by a lucky combination of genetic and non-genetic factors. Family studies demonstrated that about 25 % of the variation in human longevity is due to genetic factors. The search for genetic and molecular basis of aging has led to the identification of genes correlated with the maintenance of the cell and of its basic metabolism as the main genetic factors affecting the individual variation of the aging phenotype. In addition, studies on calorie restriction and on the variability of genes associated with nutrient-sensing signaling, have shown that ipocaloric diet and/or a genetically efficient metabolism of nutrients, can modulate lifespan by promoting an efficient maintenance of the cell and of the organism. Recently, epigenetic studies have shown that epigenetic modifications, modulated by both genetic background and lifestyle, are very sensitive to the aging process and can either be a biomarker of the quality of aging or influence the rate and the quality of aging. On the whole, current studies are showing that interventions modulating the interaction between genetic background and environment is essential to determine the individual chance to attain longevity.

Keywords: Calorie restriction; Genetics of aging; Human longevity.

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References

    1. Johnson TE. A personal retrospective on the genetics of aging. Biogerontology. 2002;3(1–2):7–12. doi: 10.1023/A:1015270322517. - DOI - PubMed
    1. Johnson TE, Wood WB. Genetic analysis of life-span in Caenorhabditis elegans. Proc Natl Acad Sci USA. 1982;79(21):6603–6607. doi: 10.1073/pnas.79.21.6603. - DOI - PMC - PubMed
    1. Johnson TE. Aging can be genetically dissected into component processes using long-lived lines of Caenorhabditis elegans. Proc Natl Acad Sci USA. 1987;84(11):3777–3781. doi: 10.1073/pnas.84.11.3777. - DOI - PMC - PubMed
    1. Friedman DB, Johnson TE. Three mutants that extend both mean and maximum life span of the nematode, Caenorhabditis elegans, define the age-1 gene. J Gerontol. 1988;43(4):B102–B109. doi: 10.1093/geronj/43.4.B102. - DOI - PubMed
    1. Kenyon C, Chang J, Gensch E, Rudner A, Tabtiang R. A C. elegans mutant that lives twice as long as wild type. Nature. 1993;366(6454):461–464. doi: 10.1038/366461a0. - DOI - PubMed

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