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. 2016 Apr 7;7(4):e2182.
doi: 10.1038/cddis.2016.86.

Neuroprotective and neurorestorative potential of xenon

J Lavaur  1 , M Lemaire  2 , J Pype  2 , D Le Nogue  1 , E C Hirsch  1 , P P Michel  1
Affiliations

Neuroprotective and neurorestorative potential of xenon

J Lavaur et al. Cell Death Dis. .
No abstract available

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Conflict of interest statement

ML and JP are Air Liquide employees. DLN is recipient of a CIFRE fellowship co-funded by Association Nationale de la Recherche et de la Technologie (ANRT) and Air Liquide Healthcare. The remaining authors declare no conflict of interest.

Figures

Figure 1
Figure 1
Simplified scheme describing the effects of xenon on cortical neurons and basal forebrain cholinergic neurons. (a) Protective effects of xenon (Xe) in cortical cultures treated with PDC to generate sustained, low-level excitotoxic stress. Xenon (75%) afforded robust but partial protection in this experimental setting. This effect was improved by a co-treatment with the noncompetitive NMDA receptor antagonist memantine (MEM), at a concentration that had no protective effect in itself (low MEM). This suggests that xenon and MEM acted cooperatively to promote neuronal survival. When MEM was used alone, at an optimal concentration (high MEM), virtually all cortical neurons were rescued. Note that a similar response profile was observed when MEM was replaced with the NMDA receptor antagonist, ketamine (not shown). (b) Xenon also stimulated cholinergic traits and promoted the morphological differentiation of cholinergic neurons in basal forebrain septal cultures. ±Means with or without treatment
See this image and copyright information in PMC

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