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. 1989 Jan;32(1):105-8.
doi: 10.1002/ajmg.1320320122.

The genetics of Crohn disease: complex segregation analysis of a family study with 265 patients with Crohn disease and 5,387 relatives

W Küster  1 , L Pascoe, J Purrmann, S Funk, F Majewski
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The genetics of Crohn disease: complex segregation analysis of a family study with 265 patients with Crohn disease and 5,387 relatives

W Küster et al. Am J Med Genet. 1989 Jan.

Abstract

We have analysed the pedigrees of 265 probands with Crohn disease, collected from a specialty clinic at the University of Düsseldorf. Complex segregation analysis suggests the presence of a recessive gene with incomplete penetrance for susceptibility to the disease with no residual causes of family resemblance. However, a proportion of the isolated cases are probably due to phenocopies, this proportion being greatest among cases with an advanced age of onset.

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