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Review
. 2016 Jun 14;37(23):1789-98.
doi: 10.1093/eurheartj/ehw113. Epub 2016 Apr 7.

Position Paper of the European Society of Cardiology Working Group Cellular Biology of the Heart: cell-based therapies for myocardial repair and regeneration in ischemic heart disease and heart failure

Rosalinda Madonna  1 , Linda W Van Laake  2 , Sean M Davidson  3 , Felix B Engel  4 , Derek J Hausenloy  5 , Sandrine Lecour  6 , Jonathan Leor  7 , Cinzia Perrino  8 , Rainer Schulz  9 , Kirsti Ytrehus  10 , Ulf Landmesser  11 , Christine L Mummery  12 , Stefan Janssens  13 , James Willerson  14 , Thomas Eschenhagen  15 , Péter Ferdinandy  16 , Joost P G Sluijter  17
Affiliations
Review

Position Paper of the European Society of Cardiology Working Group Cellular Biology of the Heart: cell-based therapies for myocardial repair and regeneration in ischemic heart disease and heart failure

Rosalinda Madonna et al. Eur Heart J. .

Abstract

Despite improvements in modern cardiovascular therapy, the morbidity and mortality of ischaemic heart disease (IHD) and heart failure (HF) remain significant in Europe and worldwide. Patients with IHD may benefit from therapies that would accelerate natural processes of postnatal collateral vessel formation and/or muscle regeneration. Here, we discuss the use of cells in the context of heart repair, and the most relevant results and current limitations from clinical trials using cell-based therapies to treat IHD and HF. We identify and discuss promising potential new therapeutic strategies that include ex vivo cell-mediated gene therapy, the use of biomaterials and cell-free therapies aimed at increasing the success rates of therapy for IHD and HF. The overall aim of this Position Paper of the ESC Working Group Cellular Biology of the Heart is to provide recommendations on how to improve the therapeutic application of cell-based therapies for cardiac regeneration and repair.

Keywords: Cell-based therapy; Heart Failure; Heart Regeneration; Heart repair; Ischaemic heart disease.

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Figure 1
Figure 1
Flowchart of experimental design starting from preclinical studies and ending to the human clinical trials.
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