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. 1978 Apr;57(4):345-8.
doi: 10.1111/j.1600-0404.1978.tb04508.x.

Reversibility of the blood-brain barrier dysfunction induced by acute hypertension

B B Johansson, L E Linder

Reversibility of the blood-brain barrier dysfunction induced by acute hypertension

B B Johansson et al. Acta Neurol Scand. 1978 Apr.

Abstract

An acute hypertensive episode of short duration (less than 3 min) induced by i.v. injection of angiotensin in rats resulted in a blood-brain barrier dysfunction that was rapidly reversible. Thus, no macroscopic extravasation was seen when Evans blue was given 10 or 20 min after angiotensin. A faint fluorescence (Evans blue-albumin) was seen in the walls of some intracerebral arterioles in a few rats given the tracer 10 min after angiotensin.

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