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. 2016 Jul 1;63(1):133-137.
doi: 10.1093/cid/ciw213. Epub 2016 Apr 7.

Antiretroviral Drug Resistance Among Children and Youth in the United States With Perinatal HIV

Russell B Van Dyke  1 , Kunjal Patel  2 , Ron M Kagan  3 , Brad Karalius  2 , Shirley Traite  4 , William A Meyer 3rd  5 , Katherine K Tassiopoulos  2 , George R Seage 3rd  2 , Lorna M Seybolt  6 , Sandra Burchett  7 , Rohan Hazra  8 ; Pediatric HIV/AIDS Cohort Study (PHACS); Robert H Lurie, Ram Yogev, Margaret Ann Sanders, Kathleen Malee, Scott Hunter, William Shearer, Mary Paul, Norma Cooper, Lynnette Harris, Murli Purswani, Mahboobullah Baig, Anna Cintron, Ana Puga, Sandra Navarro, Patricia Garvie, James Blood, Sandra Burchett, Nancy Karthas, Betsy Kammerer, Andrew Wiznia, Marlene Burey, Molly Nozyce, Arry Dieudonne, Linda Bettica, Susan Adubato, Janet Chen, Maria Garcia Bulkley, Latreaca Ivey, Mitzie Grant, Katherine Knapp, Kim Allison, Megan Wilkins, Midnela Acevedo-Flores, Heida Rios, Vivian Olivera, Margarita Silio, Medea Jones, Patricia Sirois, Stephen Spector, Kim Norris, Sharon Nichols, Elizabeth McFarland, Alisa Katai, Jennifer Dunn, Suzanne Paul, Gwendolyn Scott, Patricia Bryan, Elizabeth Willen
Affiliations

Antiretroviral Drug Resistance Among Children and Youth in the United States With Perinatal HIV

Russell B Van Dyke et al. Clin Infect Dis. .

Abstract

Among 234 US youths with perinatal human immunodeficiency virus, 75% had antiretroviral resistance, substantially higher than that of the reference laboratory overall (36%-44%). Resistance to newer antiretrovirals and to all antiretrovirals in a class was uncommon. The only factor independently associated with future resistance was a higher peak viral load.

Keywords: adolescents; antiviral resistance; children; human immunodeficiency virus; perinatal infection.

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