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. 2016:2016:1381760.
doi: 10.1155/2016/1381760. Epub 2016 Jan 12.

The Correlation of Serums CCL11, CCL17, CCL26, and CCL27 and Disease Severity in Patients with Urticaria

Tao Lu  1 , Xiaoyang Jiao  2 , Mengya Si  2 , Ping He  2 , Jinbo Zou  3 , Shuping Zhang  3 , Kang Zeng  4
Affiliations

The Correlation of Serums CCL11, CCL17, CCL26, and CCL27 and Disease Severity in Patients with Urticaria

Tao Lu et al. Dis Markers. 2016.

Abstract

Background: Chemokines may be involved in the pathogenesis of urticaria, but their correlation with disease severity as well as eruption type is unclear.

Objectives: The aim of this study was to explore the expression of chemokines in patients with urticaria. The association between disease severity and levels of chemokines was analysed.

Materials and methods: Serums CCL11, CCL17, CCL26, and CCL27, D-dimer, C-reactive protein, and total IgE were measured in 51 patients with urticaria and in 25 healthy control subjects.

Results: Serums CCL11, CCL17, CCL26, and CCL27 were significantly higher in patients with urticaria than in the healthy controls (P < 0.05). Serum CCL27 strongly correlated with urticarial disease severity. Serums CCL17, CCL26, and CCL27 significantly correlated with D-dimer, while innercorrelations were noted among the chemokines.

Conclusion: Our findings reveal that chemokines participate in the pathogenesis of urticaria. Further study in larger cohort is needed to testify whether they could be the biomarkers for predicting the severity of urticaria.

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Figures

Figure 1
Figure 1
Levels of CCL27 and CCL17 in AU, CSU, and control group (a). Levels of CCL11 and CCL26 in AU, CSU, and control group (b). Levels of CCL27 and CCL17 in different severity and control group (c). Levels of CCL11 and CCL26 in different severity and control group (d).
Figure 2
Figure 2
Correlations existed among chemokine biomarker and conventional parameters. Positive correlations were observed between CCL27 and CCL11 (a), between CCL27 and CCL11 (b), between CCL27 and CCL26 (c), between CCL17 and CCL26 (d), between CCL17 and CCL11 (e), between CCL11 and CCL26 (f), between CCL27 and CRP (g), between CCL26 and CRP (h), between CRP and D-dimer (i), between CCL27 and D-dimer (j), between CCL17 and D-dimer (k), between CCL26 and D-dimer (l), between CCL27 and levels of severe disease (m), and between D-dimer and levels of severe disease (n).
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References

    1. Zuberbier T., Asero R., Bindslev-Jensen C., et al. EAACI/GA2LEN/EDF/WAO guideline: definition, classification and diagnosis of urticaria. Allergy. 2009;64(10):1417–1426. doi: 10.1111/j.1398-9995.2009.02179.x. - DOI - PubMed
    1. Darlenski R., Kazandjieva J., Zuberbier T., Tsankov N. Chronic urticaria as a systemic disease. Clinics in Dermatology. 2014;32(3):420–423. doi: 10.1016/j.clindermatol.2013.11.009. - DOI - PubMed
    1. Puxeddu I., Italiani P., Giungato P., et al. Free IL-18 and IL-33 cytokines in chronic spontaneous urticaria. Cytokine. 2013;61(3):741–743. doi: 10.1016/j.cyto.2013.01.015. - DOI - PubMed
    1. Commins S. P., Borish L., Steinke J. W. Immunologic messenger molecules: cytokines, interferons, and chemokines. Journal of Allergy and Clinical Immunology. 2010;125(2):S53–S72. doi: 10.1016/j.jaci.2009.07.008. - DOI - PubMed
    1. Sugaya M. Chemokines and skin diseases. Archivum Immunologiae et Therapiae Experimentalis. 2014;63(2):109–115. doi: 10.1007/s00005-014-0313-y. - DOI - PubMed

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