Developmental aspects of maternal-fetal, and infant gut microbiota and implications for long-term health

Abstract

Background: Early life interactions between the human host and microbes set the stage for future health and disease.

Findings: In this review, some of the relationship of the human microbiome effects will be discussed as they relate to preterm delivery, early life diseases seen in prematurely delivered infants, and other childhood and adult maladies which include autoimmunity, allergic diseases, obesity or a healthy phenotype.

Conclusion: Although the data in these areas is just beginning to emerge, this review will provide a brief summary of some of the key research being done and will also speculate on emerging areas where major questions are being raised.

Keywords: Development; Fetus; Microbiome; Neonate.

Figure 1

Morbidities related to preterm birth also relate to prenatal dysbiosis. The fetal immune system and inflammatory responses are rapidly evolving before birth. The microbial environment may enhance or blunt immune and inflammatory responses.