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. 2016 Apr;58(4):344-50.
doi: 10.1097/JOM.0000000000000705.

Transcriptional Pathways Altered in Response to Vibration in a Model of Hand-Arm Vibration Syndrome

Stacey Waugh  1 , Michael L Kashon, Shengqiao Li, Gerome R Miller, Claud Johnson, Kristine Krajnak
Affiliations

Transcriptional Pathways Altered in Response to Vibration in a Model of Hand-Arm Vibration Syndrome

Stacey Waugh et al. J Occup Environ Med. 2016 Apr.

Abstract

Objective: The aim of this study was to use an established model of vibration-induced injury to assess frequency-dependent changes in transcript expression in skin, artery, and nerve tissues.

Methods: Transcript expression in tissues from control and vibration-exposed rats (4 h/day for 10 days at 62.5, 125, or 250 Hz; 49 m/s, rms) was measured. Transcripts affected by vibration were used in bioinformatics analyses to identify molecular- and disease-related pathways associated with exposure to vibration.

Results: Analyses revealed that cancer-related pathways showed frequency-dependent changes in activation or inhibition. Most notably, the breast-related cancer-1 pathway was affected. Other pathways associated with breast cancer type 1 susceptibility protein related signaling, or associated with cancer and cell cycle/cell survivability were also affected.

Conclusion: Occupational exposure to vibration may result in DNA damage and alterations in cell signaling pathways that have significant effects on cellular division.

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Conflict of interest statement

There are no conflicts of interest, or additional funding sources to declare.

Figures

FIGURE 1
FIGURE 1
Heat maps of transcripts that changed in the skin in response to restraint or vibration exposure of different frequencies are displayed in each figure (changes are from cage control condition). Transcript names that are in color are transcripts that appear to be associated with changes in cell cycle regulation or cancer development in more than one region of the body. Transcript names that are in black may only be associated with cell cycle regulation or cancer in a single region.
FIGURE 2
FIGURE 2
Changes in transcriptional pathways relative to unexposed controls in the skin are presented in this graph. The five pathways shown had the greatest number of transcripts changing in response to restraint or vibration. Pathways highlighted in gray may play a role in mediating cancer risk. Missing bars mean that there were no significant changes in these pathways at those frequencies.
FIGURE 3
FIGURE 3
Changes in transcriptional pathways relative to unexposed controls in the ventral tail artery are presented in this graph. Pathways highlighted in gray may play a role in mediating cancer risk.
FIGURE 4
FIGURE 4
Changes in transcriptional pathways relative to unexposed controls in ventral tail nerve. The pathways highlighted in gray play a role in cell survival/replication and cell death. The transcripts in these pathways may be involved in development or mediate the risk of developing cancer by affecting cell cycle. Missing bars mean that there were no significant changes in these pathways at those frequencies.
FIGURE 5
FIGURE 5
Various pathways that are affected by restraint and vibration and may interact to regulate development, cell division, and the risk of developing cancer are presented in this figure. The blue lines between pathways represent known interaction, the dashed lines represented hypothesized interactions, and the red line represents one mechanism by which vibration may act to affect these various pathways.
See this image and copyright information in PMC

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