Insulin Signaling in a Bit of a Jam
- PMID: 27058657
- DOI: 10.1016/j.cell.2016.03.012
Insulin Signaling in a Bit of a Jam
Abstract
In this issue of Cell, Okin and Medzhitov report that sustained inflammation promotes hyperglycemia by targeting the mevalonate pathway. This represents an important step forward in understanding the mechanisms underlying the association between chronic low-grade inflammation and disruption of normal tissue functions in metabolic diseases.
Copyright © 2016 Elsevier Inc. All rights reserved.
Comment on
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The Effect of Sustained Inflammation on Hepatic Mevalonate Pathway Results in Hyperglycemia.Cell. 2016 Apr 7;165(2):343-56. doi: 10.1016/j.cell.2016.02.023. Epub 2016 Mar 17. Cell. 2016. PMID: 26997483 Free PMC article.
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