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Review
. 2016 Apr 7;165(2):272-5.
doi: 10.1016/j.cell.2016.03.031.

Combination Cancer Therapies with Immune Checkpoint Blockade: Convergence on Interferon Signaling

Andy J Minn  1 , E John Wherry  2
Affiliations
Free article
Review

Combination Cancer Therapies with Immune Checkpoint Blockade: Convergence on Interferon Signaling

Andy J Minn et al. Cell. .
Free article

Abstract

Improving efficacy of immune checkpoint blockade for cancer can be facilitated by combining these agents with each other and/or with other conventional or targeted therapies. Interferon and innate immune signaling pathways in immune and tumor cells have emerged as intriguing determinants of response and resistance, often in complex and seemingly paradoxical ways.

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