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Comment
. 2016 Apr 7;62(1):5-6.
doi: 10.1016/j.molcel.2016.03.027.

Applying the Airbrakes: Treating Mitochondrial Disease with Hypoxia

Oliver M Russell  1 , Robert N Lightowlers  1 , Doug M Turnbull  2
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Comment

Applying the Airbrakes: Treating Mitochondrial Disease with Hypoxia

Oliver M Russell et al. Mol Cell. .
Free article

Abstract

A paper from Jain et al. (2016) using whole-genome CRISPR knockout libraries in human cells and models of mitochondrial disease suggests chronic hypoxia could be an unexpected treatment for disorders of mitochondrial respiration.

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  • Hypoxia as a therapy for mitochondrial disease.
    Jain IH, Zazzeron L, Goli R, Alexa K, Schatzman-Bone S, Dhillon H, Goldberger O, Peng J, Shalem O, Sanjana NE, Zhang F, Goessling W, Zapol WM, Mootha VK. Jain IH, et al. Science. 2016 Apr 1;352(6281):54-61. doi: 10.1126/science.aad9642. Epub 2016 Feb 25. Science. 2016. PMID: 26917594 Free PMC article.

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