Organo- and Organometallic-Catalytic Intramolecular [1,5]-Hydride Transfer/Cyclization Process through C(sp(3) )-H Bond Activation

Abstract

The direct functionalization of C(sp(3) )-H bonds is one of the most synthetically powerful research areas in current organic synthesis. Organocatalytic C(sp(3) )-H bond activation reactions have recently been developed in addition to the traditional metal-catalyzed C(sp(3) )-H activation reactions. In this review, we aim to give a brief overview of organo- and organometallic internal redox cascade reactions with respect to the mechanism, the reactivity of hydrogen donors and acceptors, and the migration modes of hydrogen.

Keywords: C(sp3)-H activation; [1,5]-hydride transfer/cyclization; atom economy; organocatalysis; redox chemistry.