Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2016 May;20(2):325-38.
doi: 10.1016/j.cld.2015.10.003. Epub 2015 Dec 14.

The Progression and Natural History of Pediatric Nonalcoholic Fatty Liver Disease

Nidhi P Goyal  1 , Jeffrey B Schwimmer  2
Affiliations
Review

The Progression and Natural History of Pediatric Nonalcoholic Fatty Liver Disease

Nidhi P Goyal et al. Clin Liver Dis. 2016 May.

Abstract

Nonalcoholic fatty liver disease (NAFLD) is the most common cause of chronic liver disease in the United States. Childhood NAFLD is associated with hepatic and nonhepatic morbidity and mortality. Nonhepatic associations include cardiovascular, metabolic, pulmonary, and psychological disorders. Cardiovascular conditions observed in childhood include left ventricular dysfunction. Furthermore, childhood obesity is associated with greater odds of having hepatocellular carcinoma as an adult. Evidence suggests that NAFLD may begin in utero in children of diabetic mothers. Thus rigorous efforts for structured diagnosis and follow-up are a priority to better develop the understanding of outcomes in pediatric NAFLD.

Keywords: Adolescents; Children; Epidemiology; Morbidity; Mortality; Nonalcoholic steatohepatitis; Obesity; Outcomes.

PubMed Disclaimer

References

    1. Brumbaugh DE, et al. Intrahepatic fat is increased in the neonatal offspring of obese women with gestational diabetes. J Pediatr. 2013;162(5):930–936. e1. - PMC - PubMed
    1. Modi N, et al. The influence of maternal body mass index on infant adiposity and hepatic lipid content. Pediatr Res. 2011;70(3):287–291. - PubMed
    1. Patel KR, White FV, Deutsch GH. Hepatic steatosis is prevalent in stillborns delivered to women with diabetes mellitus. J Pediatr Gastroenterol Nutr. 2015;60(2):152–158. - PubMed
    1. Nobili V, et al. A protective effect of breastfeeding on the progression of non-alcoholic fatty liver disease. Arch Dis Child. 2009;94(10):801–805. - PubMed
    1. Schwimmer JB, et al. Prevalence of fatty liver in children and adolescents. Pediatrics. 2006;118(4):1388–1393. - PubMed

Publication types