Creating chemotherapeutic-resistant breast cancer cell lines: advances and future perspectives

Abstract

The development of resistance remains the most significant impediment to generating effective treatments for cancer. In the modern age of personalized medicine, it is of critical importance to understand the principles of both innate and acquired resistance to achieve the most effective therapeutic outcomes. Significant differences exist between cancer cells that exhibit innate resistance verses those that acquire resistance over time. Studying the acquisition of resistance is essential to obtaining a complete understanding of how treatments contribute to disease recurrence and progression. This review will evaluate the current understanding of chemotherapeutic resistance and its role in personalized medicine. This review will also explore how generating resistant cells in culture is essential to the development of improved cancer therapeutics.

Keywords: acquired resistance; breast cancer; breast cancer stem cells; cell culture; chemoresistance; chemotherapy; innate resistance; personalized medicine; precision medicine.