Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Comparative Study
. 2016 Mar:6:54-56.
doi: 10.1016/j.msard.2016.01.004. Epub 2016 Jan 19.

Disease onset in familial and sporadic multiple sclerosis in Argentina

J I Rojas  1 , L Patrucco  2 , J MIguez  2 , V Sinay  3 , F Pagani Cassara  3 , F Cáceres  4 , N Fernandez Liguori  5 , M L Saladino  5 , N Deri  6 , G Jaacks  6 , M Parada Marcilla  7 , M I Arrigoni  8 , J Correale  9 , M Fiol  9 , M C Ysrraelit  9 , A Carrá  10 , M C Curbelo  10 , A Martinez  10 , J Steinberg  10 , S Bestoso  11 , J P Hryb  12 , J L Di Pace  12 , M B Perassolo  12 , E Carnero Contentti  13 , A Caride  13 , P A Lopez  13 , C Martinez  7 , E Reich  14 , E Cristiano  2
Affiliations
Comparative Study

Disease onset in familial and sporadic multiple sclerosis in Argentina

J I Rojas et al. Mult Scler Relat Disord. 2016 Mar.

Abstract

The present study was carried out to assess if there is an anticipation of age at onset in younger generations of familial multiple sclerosis (FMS) vs. sporadic MS (SMS) in Argentina.

Methods: multicenter study that included patients from 14 MS Centers of Argentina. Patients were considered as FMS if they had in their family at least one relative of first or second degree diagnosed with MS; otherwise, patients were considered to have SMS. We compared the age at onset between familial and sporadic cases as well as the age at onset between relatives from different generations in FMS vs. SMS.

Results: 1333 patients were included, 97 of them were FMS (7.3%). A lower age at onset in the younger generations of FMS cases was found compared with older generations of FMS as well as. SMS cases (24.1±3.7 years vs. 30.3±5.7 years, and 32.4±9.4 respectively; p<0.001). No differences were observed between older generations of FMS vs. SMS cases (p=0.12).

Conclusion: we observed an anticipation of age at onset of MS in younger generations of patients with FMS vs. older generations of FMS and SMS.

Keywords: Argentina; Familial MS; Multiple sclerosis; South America.

PubMed Disclaimer

LinkOut - more resources