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. 1989;51(1):95-115.
doi: 10.1007/BF02458838.

Codon preference and primary sequence structure in protein-coding regions

S Tavaré, B Song

Codon preference and primary sequence structure in protein-coding regions

S Tavaré et al. Bull Math Biol. 1989.

Abstract

The stochastic complexity of a data base of 365 protein-coding regions is analysed. When the primary sequence is modeled as a spatially homogeneous Markov source, the fit to observed codon preference is very poor. The situation improves substantially when a non-homogeneous model is used. Some implications for the estimation of species phylogeny and substitution rates are discussed.

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