Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Comment
. 2016 Mar 31:10:25.
doi: 10.3389/fncir.2016.00025. eCollection 2016.

Commentary: Robust quantification of orientation selectivity and direction selectivity

Tzvetomir Tzvetanov  1
Affiliations
Comment

Commentary: Robust quantification of orientation selectivity and direction selectivity

Tzvetomir Tzvetanov. Front Neural Circuits. .
No abstract available

Keywords: fitting; neuronal data analysis; neuronal tuning; sampling; statistics.

PubMed Disclaimer

Figures

Figure 1
Figure 1
Illustration of tuning, index variations, and statistical decision about tuning presence. (A) Examples of two theoretical orientation-tuned cells only differing in background firing rate (r0 of 10 and 30 Hz; Gaussian curves with amplitudes of 40 Hz and σ of 25°) and their associated OI/OB (A, amplitude; hwhm, half-width at half-maximum). (B) Illustration of the variation of the orientation bias index (Leventhal et al., 1995) for Gaussian orientation-tuned cells when only one of the three parameters varies, with the two other fixed (see legend), demonstrating the difficulty of interpreting OI/OB variables without knowledge of the tuning parameters. (C) Proportion of detected tuned cells of a given amplitude (abscissa) when applying the Hotelling T2-test (red curves) or F-test (black curves), and for two different background firing rates (5 Hz in solid lines, 30 Hz in dashed lines). The model response was a von Mises direction-tuned cell (parameters: r0, a1 = 50 Hz, a2 = 0 Hz, k = 0.95, giving hwhm~32.6°; see Swindale, 1998), experimental sampling was every 15° (e.g., Schmolesky et al., 2000) with 10 repetitions per direction, and random noise around the mean was simulated as Poisson type. A total of 200 cells were simulated for each amplitude (each symbol in the plot) with random jitter of the preferred orientation across simulations within a 40° window. Each simulation was fitted with the von Mises two amplitude function (here unconstrained), and the statistical tests applied at α = 0.05/100 for multiple tests adjustment (Matlab code available on demand, or on http://www.researchgate.net/profile/Tzvetomir_Tzvetanov).
See this image and copyright information in PMC

Comment on

References

    1. Halsey L. G., Curran-Everett D., Vowler S. L., Drummond G. B. (2016). Response to Lazzeroni et al. Nat. Methods 13, 108. 10.1038/nmeth.3745 - DOI - PubMed
    1. Lazzeroni L. C., Lu Y., Belitskaya-Lévy I. (2016). Solutions for quantifying P-value uncertainty and replication power. Nat. Methods 13, 107–108. 10.1038/nmeth.3741 - DOI - PubMed
    1. Leventhal A., Thompson K., Liu D., Zhou Y., Ault S. (1995). Concomitant sensitivity to orientation, direction, and color of cells in layers 2, 3, and 4 of monkey striate cortex. J. Neurosci. 15, 1808–1818. - PMC - PubMed
    1. Leventhal A. G., Wang Y., Pu M., Zhou Y., Ma Y. (2003). GABA and its agonists improved visual cortical function in senescent monkeys. Science 300, 812–815. 10.1126/science.1082874 - DOI - PubMed
    1. Mazurek M., Kager M., van Hooser S. D. (2014). Robust quantification of orientation selectivity and direction selectivity. Front. Neural Circuits 8:92. 10.3389/fncir.2014.00092 - DOI - PMC - PubMed

Publication types

LinkOut - more resources