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. 1977 Oct;74(10):4243-7.
doi: 10.1073/pnas.74.10.4243.

Chemical basis for brain-specific serine transfer RNAs

H Rogg, P Müller, G Keith, M Staehelin

Chemical basis for brain-specific serine transfer RNAs

H Rogg et al. Proc Natl Acad Sci U S A. 1977 Oct.

Abstract

Serine tRNA from rat brain can be resolved into six isoaccepting species. Three of these species show the same chromatographic behavior as the seryl tRNAs from other rat organs, whereas the remaining species appear to be specific for brain. The isoacceptor tRNAs were purified to homogeneity by chromatography on benzoylated DEAE-cellulose followed by reversed-phase chromatography. We found that the additional species of serine tRNA in brain differ from their counterparts derived from other rat organs by a lack of a specific guanosine ribose-methylation in the dihydrouridine loop. In addition, when total liver tRNA was compared with total brain tRNA, the same degree of undermethylation with respect to 2'-O-methylguanosine was found as a general phenomenon.

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References

    1. Proc Natl Acad Sci U S A. 1968 Jan;59(1):208-15 - PubMed
    1. Nature. 1968 Sep 28;219(5161):1363-5 - PubMed
    1. Biochem Biophys Res Commun. 1974 Feb 4;56(3):807-14 - PubMed
    1. Proc Natl Acad Sci U S A. 1973 Apr;70(4):1041-5 - PubMed
    1. Cancer Res. 1971 May;31(5):697-700 - PubMed

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