Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2016 May 23;60(6):3854-5.
doi: 10.1128/AAC.00442-16. Print 2016 Jun.

Impact of Cefepime Susceptible-Dose-Dependent MIC for Enterobacteriaceae on Reporting and Prescribing

Christina G Rivera  1 , Prasanna P Narayanan  2 , Robin Patel  3 , Lynn L Estes  4
Affiliations

Impact of Cefepime Susceptible-Dose-Dependent MIC for Enterobacteriaceae on Reporting and Prescribing

Christina G Rivera et al. Antimicrob Agents Chemother. .

Abstract

The CLSI cefepime breakpoints were revised to include a susceptible-dose-dependent (SDD) category for Enterobacteriaceae, with the intention that higher cefepime doses be used for these isolates. In this study, 1.6% of Enterobacteriaceae isolates were reported as SDD, with Escherichia coli the most common SDD organism. Cefepime was prescribed in three cases (4.8%); the majority of SDD isolates were treated with a carbapenem. Enterobacteriaceae with cefepime SDD MICs were not commonly treated with cefepime at our institution.

PubMed Disclaimer

References

    1. Alves MD, Ribeiro VB, Tessari JP, Mattiello F, De Bacco G, Luz DI, Vieira FJ, Behle TF, Pasqualotto AC, Zavascki AP. 2014. Effect of cefepime dose on mortality of patients with Gram-negative bacterial bloodstream infections: a prospective cohort study. J Antimicrob Chemother 69:1681–1687. doi:10.1093/jac/dku001. - DOI - PubMed
    1. Craig WA. 1995. Interrelationship between pharmacokinetics and pharmacodynamics in determining dosage regimens for broad-spectrum cephalosporins. Diagn Microbiol Infect Dis 22:89–96. doi:10.1016/0732-8893(95)00053-D. - DOI - PubMed
    1. Wagner JL, Kenney RM, Tibbetts RJ, Davis SL. 2015. Secular trends associated with Enterobacteriaceae with a cefepime susceptible-dose-dependent MIC. Antimicrob Agents Chemother 59:1822–1823. doi:10.1128/AAC.04491-14. - DOI - PMC - PubMed
    1. Clinical and Laboratory Standards Institute. 2013. Cefepime breakpoint change for Enterobacteriaceae and introduction of the susceptible-dose dependent (SDD) interpretive category [press release]. CLSI, Wayne, PA: community.clsi.org/micro/wp-content/uploads/sites/15/2013/07/Cefepime-BP....
    1. Hamada Y, Sutherland CA, Nicolau DP. 2015. Impact of revised cefepime CLSI breakpoints on Escherichia coli and Klebsiella pneumoniae susceptibility and potential impact if applied to Pseudomonas aeruginosa. J Clin Microbiol 53:1712–1714. doi:10.1128/JCM.03652-14. - DOI - PMC - PubMed

MeSH terms

LinkOut - more resources