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. 2016 Jun 20;60(7):4339-41.
doi: 10.1128/AAC.00504-16. Print 2016 Jul.

New Ceftriaxone- and Multidrug-Resistant Neisseria gonorrhoeae Strain with a Novel Mosaic penA Gene Isolated in Japan

Shu-Ichi Nakayama  1 , Ken Shimuta  1 , Kei-Ichi Furubayashi  2 , Takuya Kawahata  3 , Magnus Unemo  4 , Makoto Ohnishi  5
Affiliations

New Ceftriaxone- and Multidrug-Resistant Neisseria gonorrhoeae Strain with a Novel Mosaic penA Gene Isolated in Japan

Shu-Ichi Nakayama et al. Antimicrob Agents Chemother. .

Abstract

We have characterized in detail a new ceftriaxone- and multidrug-resistant Neisseria gonorrhoeae strain (FC428) isolated in Japan in 2015. FC428 differed from previous ceftriaxone-resistant strains and contained a novel mosaic penA allele encoding a new mosaic penicillin-binding protein 2 (PBP 2). However, the resistance-determining 3'-terminal region of penA was almost identical to the regions of two previously reported ceftriaxone-resistant strains from Australia and Japan, indicating that both ceftriaxone-resistant strains and conserved ceftriaxone resistance-determining PBP 2 regions might spread.

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Figures

FIG 1
FIG 1
Mosaic penA genes of the ceftriaxone-resistant Neisseria gonorrhoeae strains FC428 (present study), GU140106 (5), A8806 (8), and the ceftriaxone-susceptible genome-sequenced gonococcal strain FA1090. Sequence similarities of penAFC428 (GenBank accession no. LC113953), penAGU140106 (GenBank accession no. LC056026), penAA8806 (D. M. Whiley, personal communication), and penAFA1090 (GenBank accession no. AE004969) are shown by rectangles. The regions conserved among ceftriaxone-resistant strains are shown by black rectangles, and unique regions of each strain are indicated by gray rectangles. The penAFA1090 and penA regions in the ceftriaxone-resistant strains similar to penAFA1090 are shown by white rectangles. * indicates one nucleotide difference at position 1296 of penA: G in penAFC428, and A in penAGU140106 and penAA8806.
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