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. 1977 Oct;74(10):4392-5.
doi: 10.1073/pnas.74.10.4392.

Loop structures in hybrids of early RNA and the separated strands of adenovirus DNA

G R Kitchingman, S P Lai, H Westphal

Loop structures in hybrids of early RNA and the separated strands of adenovirus DNA

G R Kitchingman et al. Proc Natl Acad Sci U S A. 1977 Oct.

Abstract

Separated strands of adenovirus DNA were annealed with early cytoplasmic RNA and visualized in the electron microscope. DNA-RNA duplex regions within the DNA filaments could be recognized by their heavy contour. This contour was often interrupted at distinct locations by loops of displaced, single-stranded DNA. Loops have been observed and mapped in all four early regions of the genome. The structures appear to signal hitherto unknown mechanisms of eukaryotic gene expression.

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References

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