Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2016 Apr 12:42:38.
doi: 10.1186/s13052-016-0250-y.

Serum and CSF adiponectin, leptin, and interleukin 6 levels as adipocytokines in Egyptian children with febrile seizures: a cross-sectional study

Seham F Azab  1 , Mohamed A Abdalhady  2 , Mohamed A A Almalky  2 , Ezzat K Amin  2 , Dina T Sarhan  2 , Eman M Elhindawy  2 , Mayy A N Allah  2 , Ahmed A Elhewala  2 , Mohamed M A Salam  2 , Mustafa I A Hashem  2 , Attia A Soliman  2 , Nagwa E Akeel  2 , Sawsan H Abdellatif  2 , Nahla A Elsamad  2 , Anwar A Rass  2 , Manal S Arafat  3
Affiliations

Serum and CSF adiponectin, leptin, and interleukin 6 levels as adipocytokines in Egyptian children with febrile seizures: a cross-sectional study

Seham F Azab et al. Ital J Pediatr. .

Abstract

Background: A febrile seizure (FS) is the most common convulsive disorder in children. Activation of cytokine network is involved in FS pathogenesis. Adiponectin, leptin and IL-6 are the major adipocytokines secreted by fat cells. To date, only a few studies concerned the association of adipocytokines with febrile seizures. In this study, we tried to investigate serum and CSF levels of adiponectin, leptin, and interleukin-6 (IL-6); as adipocytokines, for the first time in Egyptian children with febrile seizures.

Methods: This was a prospective cross-sectional study included one hundred patients with febrile seizure, and matched with age, gender, 100 children with febrile illness without seizures (febrile control, FC) and 100 healthy control group (HC). Serum and cerebrospinal fluid (CSF) levels of adiponectin, leptin, and (IL-6) were measured by enzyme-linked immunosorbent assay (ELISA) method.

Results: Serum adiponectin was significantly higher in children with FS (16.8 ± 3.7 ug/ml) and the FC group (18.3 ± 4.3 ug/ml) compared to the HC group (9.5 ± 2.2 ug/ml); P < 0.05, respectively. Serum leptin was significantly lower in children with FS (0.9 ± 0.3 ng/ml) compared to both the FC group (4.7 ± 1.2 ng/ml) and the HC group (1.8 ± 0.4 ng/ml); P < 0.01, respectively. Children with FS had significantly higher serum IL-6 levels (43.7 ± 11.7 ng/ml) than the FC group (21.9 ± 4.5 ng/ml) and the HC group (6.5 ± 1.8 ng/ml); P < 0.01, respectively. Patients with simple febrile seizures (SFS) had serum and CSF adiponectin levels similar to those with complex febrile seizures (CFS); (P > 0.05). Serum and CSF leptin levels were significantly lower in patients with CFS compared to the SFS group (P < 0.05). Serum and CSF IL-6 levels were significantly higher in patients with CFS compared to the SFS group (P < 0.01). On multivariate logistic regression analysis, the high serum IL-6 levels was the most significant risk factor associated with febrile seizures among studied children (OR: 6.2; 95 % CI: 3.58 -10.57; P = 0.0001).

Conclusion: Our data brought a novel observation that some adipocytokines like leptin and IL-6 could be, at least in part, an aetiopathogenetic factor in the manifestation of febrile seizures in susceptible Egyptian children. Moreover, we observed a significant association between high CSF IL-6 levels and susceptibility to complex febrile seizures as did the low CSF leptin levels.

Keywords: Febrile seizure; adipocytokines; adiponectin; interleukin-6; leptin.

PubMed Disclaimer

Figures

Fig. 1
Fig. 1
Serum adiponectin level among studied groups
Fig. 2
Fig. 2
Serum leptin level among studied groups
Fig. 3
Fig. 3
Serum IL-6 level among studied groups
See this image and copyright information in PMC

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

References

    1. Vestergaard M, Obel C, Henriksen TB, Christensen J, Madsen KM, Ostergaard JR. The Danish National Hospital Register is a valuable study base for epidemiologic research in febrile seizures. J Clin Epidemiol. 2006;59:61–66. doi: 10.1016/j.jclinepi.2005.05.008. - DOI - PubMed
    1. Habib Z, Akram S, Ibrahim S, Hasan B. Febrile seizures: factors affecting risk of recurrence in Pakistani children presenting at the Aga Khan University Hospital. J Pak Med Assoc. 2003;53(1):11–7. - PubMed
    1. Tsai F-J, Chou I, Hsieh Y-Y, Lee C-C, Lin C-C, Tsai C-H. Interleukin-4 intron 3 polymorphism is not related to susceptibility to febrile seizures. Pediatr Neurol. 2002;27:271–274. doi: 10.1016/S0887-8994(02)00434-4. - DOI - PubMed
    1. Trayhurn P, Beattie JH. Physiological role of adipose tissue: white adipose as an endocrine and secretory organ. Proc Nutr Soc. 2001;60:329–339. doi: 10.1079/PNS200194. - DOI - PubMed
    1. Carbone F, La Rocca C, Matarese G. Immunological functions of leptin and adiponectin. Biochimie. 2012;94:2082–2088. doi: 10.1016/j.biochi.2012.05.018. - DOI - PubMed

LinkOut - more resources