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Meta-Analysis
. 2016 Apr 12:22:1223-31.
doi: 10.12659/msm.895434.

Relationships of OPG Genetic Polymorphisms with Susceptibility to Cardiovascular Disease: A Meta-Analysis

De-Hua Song  1 , Peng-Zhen Zhou  1 , Xiao-Lin Xiu  1 , Guang-Hui Zhou  1 , Yu-Xia Sun  1 , Chun Song  2
Affiliations
Meta-Analysis

Relationships of OPG Genetic Polymorphisms with Susceptibility to Cardiovascular Disease: A Meta-Analysis

De-Hua Song et al. Med Sci Monit. .

Abstract

BACKGROUND The aim of this meta-analysis was to determine whether genetic polymorphisms in the osteoprotegerin (OPG) gene contribute to increased risk of cardiovascular disease (CVD). MATERIAL AND METHODS Electronic databases were searched carefully without any language restriction. Analyses of data were conducted using STATA software. Odds ratios (OR) and 95% confidence intervals (95%CI) were also calculated. RESULTS Seven clinical case-control studies that enrolled 1170 CVD patients and 1194 healthy subjects were included. The results indicated that OPG gene polymorphism might be closely associated with susceptibility to CVD, especially for rs2073617 T>C and rs2073618 G>C polymorphisms. Ethnicity-stratified analysis indicated that genetic polymorphism in the OPG were closely related with the pathogenesis of CVD among Asians (all P<0.001), but no obvious relationship was found among Caucasians (all P>0.05). CONCLUSIONS Our meta-analysis provided quantitative evidence that OPG gene polymorphism may be closely related to an increased risk of CVD, especially for rs2073617 T>C and rs2073618 G>C polymorphisms.

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Figures

Figure 1
Figure 1
Flow chart shows study selection procedure. Seven case-control studies were included in this meta-analysis.
Figure 2
Figure 2
Forest plots for the influences of OPG genetic polymorphisms and cardiovascular disease under the allele and dominant models.
Figure 3
Figure 3
Subgroup analyses for the influences of OPG genetic polymorphisms and cardiovascular disease under the allele and dominant models.
Figure 4
Figure 4
Sensitivity analysis for the influences of OPG genetic polymorphisms and cardiovascular disease under the allele and dominant models.
Figure 5
Figure 5
Funnel plot of publication biases on the relationships between genetic polymorphisms and cardiovascular disease under the allele and dominant models.
See this image and copyright information in PMC

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