Review
doi: 10.1042/BST20150264.
Structural comparison of yeast and human intra-mitochondrial lipid transport systems
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- PMID: 27068958
- DOI: 10.1042/BST20150264
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Review
Structural comparison of yeast and human intra-mitochondrial lipid transport systems
Biochem Soc Trans.
.
Abstract
Mitochondria depend on a tightly regulated supply of phospholipids. The protein of relevant evolutionary and lymphoid interest (PRELI)/Ups1 family together with its mitochondrial chaperones [TP53-regulated inhibitor of apoptosis 1 (TRIAP1)/Mdm35] represents a unique heterodimeric lipid-transfer system that is evolutionary conserved from yeast to man. Recent X-ray crystal structures of the human and yeast systems are compared and discuss here and shed new insight into the mechanism of the PRELI/Ups1 system.
Keywords: PRELI; TRIAP1; Ups1; membranes; mitochondria; phospholipid transport.
© 2016 Authors; published by Portland Press Limited.
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