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. 2016 Feb 8;2016(2):CD012082.
doi: 10.1002/14651858.CD012082.

Red blood cell transfusion to treat or prevent complications in sickle cell disease: an overview of Cochrane reviews

Affiliations

Red blood cell transfusion to treat or prevent complications in sickle cell disease: an overview of Cochrane reviews

Lise J Estcourt et al. Cochrane Database Syst Rev. .

Update in

Abstract

This is the protocol for a review and there is no abstract. The objectives are as follows: To summarize the evidence in Cochrane reviews of the effectiveness and safety of red cell transfusions versus no transfusion, or restrictive (to increase the total haemoglobin) versus liberal (to decrease the haemoglobin S level below a specified percentage) transfusion, for treatment or prevention of complications experienced by people with SCD.

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References

    1. Adams RJ, McKie VC, Hsu L, Files B, Vichinsky E, Pegelow C, et al. Prevention of a first stroke by transfusions in children with sickle cell anemia and abnormal results on transcranial doppler ultrasonography. New England Journal of Medicine. 1998;339(1):5–11. - PubMed
    1. Akinsheye I, Alsultan A, Solovieff N, Ngo D, Baldwin CT, Sebastiani P, et al. Fetal hemoglobin in sickle cell anemia. Blood. 2011;118(1):19–27. - PMC - PubMed
    1. Alhashimi D, Fedorowickz Z, Alhashimi F, Dastgiri S. Blood transfusions for treating acute chest syndrome in people with sickle cell disease. Cochrane Database of Systematic Reviews. 2010;(Issue 1) DOI: 10.1002/14651858.CD007843.pub2. - PubMed
    1. Balshem H, Helfand M, Schunemann HJ, Oxman AD, Kunz R, Brozek J, et al. GRADE Guidelines 3. rating the quality of evidence. Journal of Clinical Epidemiology. 2011;64(4):401–6. - PubMed
    1. Cho G, Hambleton JR. Regular long-term red blood cell transfusions for managing chronic chest complications in sickle cell disease. Cochrane Database of Systematic Reviews. 2014;(Issue 1) DOI: 10.1002/14651858.CD008360.pub3. - PubMed

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