Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Case Reports
. 2016 Mar 2;7(Suppl 5):S142-7.
doi: 10.4103/2152-7806.177888. eCollection 2016.

Glomangiopericytoma simulating an intracavernous meningioma

Hussam Abou Al-Shaar  1 , Kristian I Macdonald  2 , Mohamed A Labib  3
Affiliations
Case Reports

Glomangiopericytoma simulating an intracavernous meningioma

Hussam Abou Al-Shaar et al. Surg Neurol Int. .

Abstract

Background: Glomangiopericytoma is an uncommonly encountered tumor of the nose and paranasal sinuses, accounting for <0.5% of all sinonasal tumors. Extension of these lesions to the anterior or middle cranial fossa is rare. When this occurs, diagnosing glomangiopericytoma is extremely challenging, as it is often confused with other anterior skull base tumors.

Case description: We report a case of a giant glomangiopericytoma localizing into the cavernous sinus in a 48-year-old female who presented with mild left-sided ptosis for 48 months. The lesion simulated an intracavernous meningioma on preoperative imaging. An expanded endoscopic endonasal approach was used to debulk the portion of the lesion in the medial compartment of the cavernous sinus. Postoperatively, the patient's ptosis resolved completely, and no new deficits were sustained.

Conclusion: This is the only case of glomangiopericytoma localizing solely to the cavernous sinus reported to date.

Keywords: Cavernous sinus; endoscopic approach; glomangiopericytoma; meningioma; sinonasal-type hemangiopericytoma.

PubMed Disclaimer

Figures

Figure 1
Figure 1
Preoperative imaging of the glomangiopericytoma. Axial T1 magnetic resonance imaging with gadolinium (a), T1 without gadolinium (b), flair (c), T2 (d), sagittal (e), and coronal (f) T1 with gadolinium depicting the tumor in the left cavernous sinus simulating an intracavernous meningioma. Axial (g) and coronal (h) computed tomography angiography demonstrating low vascular flow to the tumor in the left cavernous sinus
Figure 2
Figure 2
Microscopic and immunohistochemical examination of the resected specimen (a and b). Low and high power microscopic examination with H and E stain demonstrating connective vascular arrangements in a kind of honeycomb structure, with a relatively thin walls consisting of endothelial cells and fibroblast-like cells in the stroma. Immunohistochemical examination of the specimen showed diffuse and strong positivity to CD34 in the endothelium alone (c) and muscle-specific actin in the stroma (d)
Figure 3
Figure 3
Immediate postoperative imaging after endoscopic tumor debulking. Axial (a and b), sagittal (c), and coronal (d) T1 magnetic resonance imaging with gadolinium depicting residual tumor in the left cavernous sinus with expected postoperative changes
Figure 4
Figure 4
Postoperative imaging 5 months after tumor debulking. Axial (a) and sagittal (b) T1 magnetic resonance imaging with gadolinium and coronal T2 (c and d) showing stable tumor with no interval growth/progression
See this image and copyright information in PMC

References

    1. Abraham SC, Montgomery EA, Giardiello FM, Wu TT. Frequent beta-catenin mutations in juvenile nasopharyngeal angiofibromas. Am J Pathol. 2001;158:1073–8. - PMC - PubMed
    1. Angouridakis N, Zaraboukas T, Vital J, Vital V. Sinonasal hemangiopericytoma of the middle turbinate: A case report and brief review of the literature. B-ENT. 2007;3:139–43. - PubMed
    1. Arpaci RB, Kara T, Vayisoglu Y, Ozgur A, Ozcan C. Sinonasal glomangiopericytoma. J Craniofac Surg. 2012;23:1194–6. - PubMed
    1. Barnes L, Eveson JW, Reichart P, Sidransky D, editors. Pathology and Genetics of Head and Neck Tumours. World Health Organization Classification of Tumours. Vol. 9. Lyon, France: IARC Press; 2005. pp. 43–4.
    1. Bhattacharyya N, Shapiro NL, Metson R. Endoscopic resection of a recurrent sinonasal hemangiopericytoma. Am J Otolaryngol. 1997;18:341–4. - PubMed

Publication types

LinkOut - more resources