Saprochaete clavata invasive infection in a patient with severe aplastic anemia: Efficacy of voriconazole and liposomal amphotericin B with adjuvant granulocyte transfusions before neutrophil recovery following allogeneic bone marrow transplantation
- PMID: 27069848
- PMCID: PMC4811851
- DOI: 10.1016/j.mmcr.2016.03.001
Saprochaete clavata invasive infection in a patient with severe aplastic anemia: Efficacy of voriconazole and liposomal amphotericin B with adjuvant granulocyte transfusions before neutrophil recovery following allogeneic bone marrow transplantation
Abstract
We report a case of a 27-year old man with severe aplastic anemia who developed a Saprochaete clavata (Geotrichum clavatum) disseminated invasive infection shortly prior a scheduled allogeneic bone marrow transplantation. Treatment with a combination of voriconazole, liposomal amphotericin B and adjuvant granulocyte transfusions was successful before neutrophil recovery.
Keywords: Aplastic anemia; Hematological disease; Invasive infection; Saprochaete clavata.
References
-
- Arendrup M.C., Boekhout T., Akova M., Meis J.F., Cornely O.A., Lortholary O. European society of clinical microbiology and infectious diseases fungal infection study group; European confederation of medical mycology. ESCMID and ECMM joint clinical guidelines for the diagnosis and management of rare invasive yeast infections. Clin. Microbiol. Infect. 2014;20(Suppl. 3):S76–S98. - PubMed
-
- Girmenia C., Pagano L., Martino B., D’Antonio D., Fanci R., Specchia G. GIMEMA Infection Program. Invasive infections caused by Trichosporon species and Geotrichum capitatum in patients with hematological malignancies: a retrospective multicenter study from Italy and review of the literature. J. Clin. Microbiol. 2005;43(4):1818–1828. - PMC - PubMed
-
- Picard M., Cassaing S., Letocart P., Verdeil X., Protin C., Chauvin P. Concomitant cases of disseminated Geotrichum clavatum infections in patients with acute myeloid leukemia. Leuk Lymphoma. 2014;55(5):1186–1188. - PubMed
-
- Camus V., Thibault M.L., David M., Gargala G., Compagnon P., Lamoureux F. Invasive Geotrichum clavatum fungal infection in an acute myeloid leukaemia patient: a case report and review. Mycopathologia. 2014;177(5–6):319–324. - PubMed
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