Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2016 Mar 8:11:21-3.
doi: 10.1016/j.mmcr.2016.03.001. eCollection 2016 Mar.

Saprochaete clavata invasive infection in a patient with severe aplastic anemia: Efficacy of voriconazole and liposomal amphotericin B with adjuvant granulocyte transfusions before neutrophil recovery following allogeneic bone marrow transplantation

Affiliations

Saprochaete clavata invasive infection in a patient with severe aplastic anemia: Efficacy of voriconazole and liposomal amphotericin B with adjuvant granulocyte transfusions before neutrophil recovery following allogeneic bone marrow transplantation

Simon Favre et al. Med Mycol Case Rep. .

Abstract

We report a case of a 27-year old man with severe aplastic anemia who developed a Saprochaete clavata (Geotrichum clavatum) disseminated invasive infection shortly prior a scheduled allogeneic bone marrow transplantation. Treatment with a combination of voriconazole, liposomal amphotericin B and adjuvant granulocyte transfusions was successful before neutrophil recovery.

Keywords: Aplastic anemia; Hematological disease; Invasive infection; Saprochaete clavata.

PubMed Disclaimer

References

    1. Vaux S., Criscuolo A., Desnos-Ollivier M., Diancourt L., Tarnaud C., Vandenbogaert M. Geotrichum investigation group. Multicenter outbreak of infections by Saprochaete clavata, an unrecognized opportunistic fungal pathogen. MBio. 2014;5(6) - PMC - PubMed
    1. Arendrup M.C., Boekhout T., Akova M., Meis J.F., Cornely O.A., Lortholary O. European society of clinical microbiology and infectious diseases fungal infection study group; European confederation of medical mycology. ESCMID and ECMM joint clinical guidelines for the diagnosis and management of rare invasive yeast infections. Clin. Microbiol. Infect. 2014;20(Suppl. 3):S76–S98. - PubMed
    1. Girmenia C., Pagano L., Martino B., D’Antonio D., Fanci R., Specchia G. GIMEMA Infection Program. Invasive infections caused by Trichosporon species and Geotrichum capitatum in patients with hematological malignancies: a retrospective multicenter study from Italy and review of the literature. J. Clin. Microbiol. 2005;43(4):1818–1828. - PMC - PubMed
    1. Picard M., Cassaing S., Letocart P., Verdeil X., Protin C., Chauvin P. Concomitant cases of disseminated Geotrichum clavatum infections in patients with acute myeloid leukemia. Leuk Lymphoma. 2014;55(5):1186–1188. - PubMed
    1. Camus V., Thibault M.L., David M., Gargala G., Compagnon P., Lamoureux F. Invasive Geotrichum clavatum fungal infection in an acute myeloid leukaemia patient: a case report and review. Mycopathologia. 2014;177(5–6):319–324. - PubMed

LinkOut - more resources