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. 2016:2016:7845438.
doi: 10.1155/2016/7845438. Epub 2016 Mar 16.

Different Multimorbidity Measures Result in Varying Estimated Levels of Physical Quality of Life in Individuals with Multimorbidity: A Cross-Sectional Study in the General Population

Aline Ramond-Roquin  1 , Jeannie Haggerty  2 , Mireille Lambert  3 , Jose Almirall  3 , Martin Fortin  4
Affiliations

Different Multimorbidity Measures Result in Varying Estimated Levels of Physical Quality of Life in Individuals with Multimorbidity: A Cross-Sectional Study in the General Population

Aline Ramond-Roquin et al. Biomed Res Int. 2016.

Abstract

Introduction: Multimorbidity adversely affects health-related quality of life. Methodological factors may impact the magnitude of this relationship.

Objective: To evaluate how physical health-related quality of life varies in individuals with multimorbidity depending on the length of the list of candidate conditions considered.

Methods: Secondary analysis from PRECISE, a cohort study of the general adult population of Quebec, Canada. Multimorbidity was measured using the 21-chronic condition list from the Disease Burden Morbidity Assessment, and physical health-related quality of life was measured using the physical component summary (PCS) of SF-12v2. The PCS was calculated, (a) using 2 or more conditions from the 21-condition list (MM2+, 21) and then from a reduced 6-condition list (MM2+, 6) and (b) using three or more conditions from each list (MM3+, 21, and MM3+, 6).

Results: The analysis included 1,710 individuals (mean age 51.3, 40.5% men). Multimorbidity prevalence ranged from 63.8% (MM2+, 21 conditions) to 3.8% (MM3+, 6 conditions). The mean [95% CI] PCS dropped from 45.7 [CI: 45.0-46.3] (MM2+, 21) to 40.2 [CI: 38.7-41.8] (MM2+, 6) and from 44.2 [CI: 43.4-44.9] (MM3+, 21) to 34.8 [CI: 31.9-37.6] (MM3+, 6).

Conclusion: The length of the list of candidate conditions considered has a great impact on the estimations of physical health-related quality of life.

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Figures

Figure 1
Figure 1
Prevalence of multimorbidity, depending on the multimorbidity measure. Operational definitions of multimorbidity: MM2+: having two or more chronic conditions; MM3+: having three or more chronic conditions.
Figure 2
Figure 2
Estimates of the average level (mean values and 95% confidence intervals) of the physical component of health-related quality of life in individuals with multimorbidity, depending on the multimorbidity measure. Operational definitions of multimorbidity: MM2+: having two or more chronic conditions; MM3+: having three or more chronic conditions.
Figure 3
Figure 3
Estimates of the average level (mean values and 95% confidence intervals) of the physical component of health-related quality of life in individuals with multimorbidity, depending on the multimorbidity measure, stratified by age (a), gender (b), and socioeconomic status (c). Operational definitions of multimorbidity: MM2+: having two or more chronic conditions; MM3+: having three or more chronic conditions. Estimates were not computed in the case of multimorbidity measured as MM3+ based on the 6-condition list for young people “25–44 years” and for the “elite” group, due to insufficient subsample size (4 and 2 individuals, resp.).
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