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. 2016 Jun;22(6):1129-31.
doi: 10.3201/eid2206.152113. Epub 2016 Jun 15.

MERS-CoV Infection of Alpaca in a Region Where MERS-CoV is Endemic

Chantal B E M Reusken, Chrispijn Schilp, V Stalin Raj, Erwin De Bruin, Robert H G Kohl, Elmoubasher A B A Farag, Bart L Haagmans, Hamad Al-Romaihi, Francois Le Grange, Berend-Jan Bosch, Marion P G Koopmans

MERS-CoV Infection of Alpaca in a Region Where MERS-CoV is Endemic

Chantal B E M Reusken et al. Emerg Infect Dis. 2016 Jun.
No abstract available

Keywords: MERS-CoV; Middle East respiratory syndrome coronavirus; Qatar; SARS-CoV; Vicugna pacos; alpaca; camelid; dromedary; severe acute respiratory syndrome coronavirus; viruses; zoonoses.

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Figures

Figure
Figure
Column scatterplots of MERS-CoV reactivity of serum samples from alpaca (n = 15) and dromedaries (n = 10) in the Al Shahaniya region of Qatar, April 2015. A) Plot of alpaca and dromedary serum titers of antibodies specific for S1 antigens of 2 coronaviruses as determined by protein microarray. Titers were defined as the interpolated serum concentration that provoked a response half-way on a concentration-response curve between the minimum and maximum signal and were calculated from the inflection point of a 4-step dilution series (1:20 to 1:1,280) as described previously (5). B) Plot of alpaca and dromedary serum titers of MERS-CoV neutralizing antibodies as determined by PRNT90. The highest serum dilution neutralizing 90% of plaque formation is depicted. For both panels, solid lines indicate median, and dotted lines indicate detection limit. MERS, Middle East respiratory syndrome; CoV, coronavirus; PRNT90, 90% plaque-reduction neutralization test; SARS, severe acute respiratory syndrome.
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