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Comment
. 2016 Apr 11;29(4):427-429.
doi: 10.1016/j.ccell.2016.03.024.

Blood-Brain Barrier Breakdown Determines Differential Therapeutic Outcome in Genetically Diverse Forms of Medulloblastoma

Sylvaine Guerit  1 , Stefan Liebner  2
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Blood-Brain Barrier Breakdown Determines Differential Therapeutic Outcome in Genetically Diverse Forms of Medulloblastoma

Sylvaine Guerit et al. Cancer Cell. .
Free article

Abstract

Medulloblastoma driven by Wnt/β-catenin and Sonic hedgehog pathway mutations show favorable and poor patient survival upon treatment, respectively. In this Cancer Cell issue, Phoenix and colleagues (2016) report disruption of the blood-brain barrier by Wif1 specifically in Wnt-driven medulloblastoma, resulting in increased treatment response and survival in mouse models.

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  • Medulloblastoma Genotype Dictates Blood Brain Barrier Phenotype.
    Phoenix TN, Patmore DM, Boop S, Boulos N, Jacus MO, Patel YT, Roussel MF, Finkelstein D, Goumnerova L, Perreault S, Wadhwa E, Cho YJ, Stewart CF, Gilbertson RJ. Phoenix TN, et al. Cancer Cell. 2016 Apr 11;29(4):508-522. doi: 10.1016/j.ccell.2016.03.002. Epub 2016 Mar 31. Cancer Cell. 2016. PMID: 27050100 Free PMC article.

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