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. 2016 Apr 11;29(4):432-434.
doi: 10.1016/j.ccell.2016.03.016.

Glycoholics Anonymous: Cancer Sobers Up with mTORC1

Vivian Fu  1 , Toshiro Moroishi  1 , Kun-Liang Guan  2
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Glycoholics Anonymous: Cancer Sobers Up with mTORC1

Vivian Fu et al. Cancer Cell. .
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Abstract

In this issue of Cancer Cell, Pusapati et al. (2016) reveal that mTORC1 orchestrates the metabolic reprogramming of cancer cells in response to glycolytic inhibitors, bypassing glycolysis by increasing glutamine uptake and pentose phosphate flux to generate energy and biomass.

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