Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2013;2(4):179-83.
doi: 10.14283/jfa.2013.26.

Klotho, FGF21 and FGF23: Novel Pathways to Musculoskeletal Health?

B Bartali  1 , R D Semba, A B Araujo
Affiliations

Klotho, FGF21 and FGF23: Novel Pathways to Musculoskeletal Health?

B Bartali et al. J Frailty Aging. 2013.

Abstract

Bone mineral density, muscle mass and physical function reach their peak between the second and fourth decade of life and then decline steadily with aging. The crucial question is: what factors contribute to or modulate this decline? The aim of this mini-review is to propose a theoretical framework for the potential role of emerging biomarkers such as klotho, fibroblast growth factors (FGF)21 and FGF23 on musculoskeletal health, with a particular focus on decline in muscle mass and function, and calls for future research to examine this proposed link. The identification of new physiological mechanisms underlying these declines may open a potentially important avenue for the development of novel intervention strategies aimed at preventing or reducing their potentially detrimental consequences.

PubMed Disclaimer

Figures

Figure 1
Figure 1
Simplified conceptual framework
See this image and copyright information in PMC

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

References

    1. Tinetti ME, Speechley M, Ginter SF. Risk factors for falls among elderly persons living in the community. New Engl J Med. 1988;319(26):1701–7. - PubMed
    1. Yamazaki Y, Imura A, Urakawa I, Shimada T, Murakami J, Aono Y, et al. Establishment of sandwich ELISA for soluble alpha-Klotho measurement: Age-dependent change of soluble alpha-Klotho levels in healthy subjects. Biochem Biophys Res Commun. 2010;398(3):513–8. - PMC - PubMed
    1. Visser M, Goodpaster BH, Kritchevsky SB, Newman AB, Nevitt M, Rubin SM, et al. Muscle mass, muscle strength, and muscle fat infiltration as predictors of incident mobility limitations in well-functioning older persons. J Gerontol A Biol Sci Med Sci. 2005;60(3):324–33. - PubMed
    1. Manton KG. The global impact of noncommunicable diseases: estimates and projections. World Health Stat Q. 1988;41(3–4):255–66. - PubMed
    1. Marsh AP, Rejeski WJ, Espeland MA, Miller ME, Church TS, Fielding RA, et al. Muscle strength and BMI as predictors of major mobility disability in the Lifestyle Interventions and Independence for Elders pilot (LIFE-P) J Gerontol A Biol Sci Med Sci. 2011;66(12):1376–83. - PMC - PubMed

LinkOut - more resources