Modulation of Human Sperm Capacitation by Progesterone, Estradiol, and Luteinizing Hormone

Abstract

Sperm residency in female reproductive tract is essential to undergo functional changes that allow the cell to encounter the oocyte and fertilize it. Those changes, known as capacitation, are modulated by molecules located in the uterotubal surface and fluids. During the fertile window, there is a notable increase in some reproductive hormones such as progesterone, estradiol, and luteinizing hormone in the female reproductive tract, so spermatozoa are exposed to these hormones in an environment that must favor gamete encountering and fusion. This spatiotemporal coincidence suggests that they are suitable candidates to modulate sperm function in order to synchronize the events that ultimately allow the success of fertilization. The presence of receptors for these hormones in the human sperm has been described, but their physiological relevance and mechanisms of action have been either subject of controversy or not properly investigated. This review intends to summarize the evidence that support the participation of these hormones in the regulation of sperm capacitation.

Keywords: estradiol; fertilization; luteinizing hormone; progesterone; sperm capacitation.