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. 1989 Jan 10;159(2):211-5.
doi: 10.1016/0014-2999(89)90709-7.

Antagonistic effects of caffeine and yohimbine in animal tests of anxiety

H A Baldwin  1 , A L Johnston, S E File
Affiliations

Antagonistic effects of caffeine and yohimbine in animal tests of anxiety

H A Baldwin et al. Eur J Pharmacol. .

Abstract

The effect of a combination of caffeine and yohimbine was investigated in the social interaction, elevated plus-maze and punished-drinking tests of anxiety. Caffeine (40 mg/kg i.p.) had anxiogenic-like effects in the social interaction and plus-maze tests. Yohimbine (2.5 mg/kg i.p.) was anxiogenic-like in the plus-maze and displayed anticonflict activity. Unexpectedly, caffeine and yohimbine antagonized each others' effects in the social interaction and elevated plus-maze tests.

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