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Comment
. 2016 Apr 13:5:e15938.
doi: 10.7554/eLife.15938.

Partners in the Warburg effect

Joshua D Rabinowitz  1 , Hilary A Coller  2   3
Affiliations
Comment

Partners in the Warburg effect

Joshua D Rabinowitz et al. Elife. .

Abstract

Cells that surround tumors produce vesicles that supply nutrients to cancer cells and, more surprisingly, also impair the generation of energy in these cancer cells.

Keywords: cancer metabolism; cell biology; exosomes; human; human biology; macropinocytosis; medicine; metabolic flux analysis; reductive carboxylation; tumor microenvironment.

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Conflict of interest statement

The authors declare that no competing interests exist.

Figures

Figure 1.
Figure 1.. Fibroblasts supply nutrients to cancer cells and inhibit oxidative phosphorylation in cancer cells.
Fibroblasts (pink cells) associate with epithelial cancer cells (blue cells) and release exosomes (circles) that transfer nutrients to epithelial cancer cells (orange lines). In addition, they inhibit mitochondrial oxidative phosphorylation in the cancer cells (black blunt arrows), perhaps via microRNAs that silence particular genes.
See this image and copyright information in PMC

Comment on

References

    1. Castellana D, Zobairi F, Martinez MC, Panaro MA, Mitolo V, Freyssinet JM, Kunzelmann C. Membrane microvesicles as actors in the establishment of a favorable prostatic tumoral niche: a role for activated fibroblasts and CX3CL1-CX3CR1 axis. Cancer Research. 2009;69:785–793. doi: 10.1158/0008-5472.CAN-08-1946. - DOI - PubMed
    1. Cirri P, Chiarugi P. Cancer-associated-fibroblasts and tumour cells: a diabolic liaison driving cancer progression. Cancer Metastasis Reviews. 2012;31:195–208. doi: 10.1007/s10555-011-9340-x. - DOI - PubMed
    1. Kamphorst JJ, Nofal M, Commisso C, Hackett SR, Lu W, Grabocka E, Vander Heiden MG, Miller G, Drebin JA, Bar-Sagi D, Thompson CB, Rabinowitz JD. Human pancreatic cancer tumors are nutrient poor and tumor cells actively scavenge extracellular protein. Cancer Research. 2015;75:544–553. doi: 10.1158/0008-5472.CAN-14-2211. - DOI - PMC - PubMed
    1. Koppenol WH, Bounds PL, Dang CV. Otto Warburg's contributions to current concepts of cancer metabolism. Nature Reviews Cancer. 2011;11:325–337. doi: 10.1038/nrc3038. - DOI - PubMed
    1. Martinez-Outschoorn UE, Lisanti MP, Sotgia F. Catabolic cancer-associated fibroblasts transfer energy and biomass to anabolic cancer cells, fueling tumor growth. Seminars in Cancer Biology. 2014;25:47–60. doi: 10.1016/j.semcancer.2014.01.005. - DOI - PubMed