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Review
. 2016:2016:7682387.
doi: 10.1155/2016/7682387. Epub 2016 Mar 17.

Smoking Exposure and Survival of Patients with Esophagus Cancer: A Systematic Review and Meta-Analysis

Jun-Jie Kuang  1 , Zhi-Min Jiang  1 , Yan-Xian Chen  1 , Wei-Peng Ye  1 , Qiong Yang  1 , Hui-Zhong Wang  1 , De-Rong Xie  1
Affiliations
Review

Smoking Exposure and Survival of Patients with Esophagus Cancer: A Systematic Review and Meta-Analysis

Jun-Jie Kuang et al. Gastroenterol Res Pract. 2016.

Abstract

Smoking is a well-known major risk factor in development of esophageal cancer, but few studies have reported the association between smoking status and prognosis of these patients. We conduct the present study to summarize current evidence. A computerized search of the PubMed and EMBASE was performed up to April 30, 2015. Eight studies, containing 4,286 patients, were analyzed. In the grouping analysis, among esophageal squamous-cell carcinoma patients, current and former smokers, compared to those who have never smoked, seemed to have a poorer prognosis (HR = 1.41, 95% CI 1.22-1.64, and HR = 1.35, 95% CI 0.92-1.97, resp.). In the subgroup analysis, adverse effects on current smoker compared with never smoker were also observed in China and the other countries (HR = 1.5, 95% CI 1.18-1.92, and HR = 1.36, 95% CI 1.12-1.65, resp.). In the group that ever smoked, we could not get a similar result. No significantly increased risk was found in esophageal adenocarcinoma patients compared to the squamous-cell histology ones. In the smoking intensity analysis, heavy smoking was associated with poor survival in esophageal squamous-cell carcinoma. Our pooled results supported the existence of harmful effects of smoking on survival after esophagus cancer diagnosis.

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Figures

Figure 1
Figure 1
Flow chart of literature search for this meta-analysis.
Figure 2
Figure 2
Current smoker versus never smoker.
Figure 3
Figure 3
The funnel plot of current versus never smoker.
Figure 4
Figure 4
Subgroup analysis of current versus never smoker.
Figure 5
Figure 5
Former versus never smoker.
Figure 6
Figure 6
Ever versus never smoker.
See this image and copyright information in PMC

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