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. 2016 Apr;4(4):597-598.
doi: 10.3892/mco.2016.775. Epub 2016 Feb 10.

Hydronephrosis associated with ureteral metastasis of prostate cancer: A rare case report

Dong Zhang  1 , Hongliang Li  1 , Weimin Gan  1
Affiliations

Hydronephrosis associated with ureteral metastasis of prostate cancer: A rare case report

Dong Zhang et al. Mol Clin Oncol. 2016 Apr.

Abstract

Prostate cancer is one of the most common male malignancies, although it rarely metastasizes to the ureter. The present case study reported a 63-year-old man who presented with asymptomatic right hydronephrosis, detected by ultrasound. Computed tomography urography demonstrated right hydronephrosis, secondary to thickening of the distal ureter. The patient's serum concentration of prostate specific antigen was 111.400 ng/ml, and a prostate needle biopsy revealed prostate adenocarcinoma, with a Gleason score of 4+5=9. Renal scintigraphy revealed poor excretion of the right kidney. A nephroureterectomy was subsequently performed, and a histological examination revealed a metastatic prostate adenocarcinoma of the ureter. Combined androgen blockage therapy with bicalutamide (50 mg, once daily) and goserelin (3.6 mg, once a month) was administered to the patient. At 3 months of follow-up, the patient's PSA levels had decreased to 0.322 ng/ml; at 6 months of follow-up, the PSA levels had further decreased to 0.136 ng/ml.

Keywords: hydronephrosis; loss of renal function; prostate cancer; ureter metastasis.

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Figures

Figure 1.
Figure 1.
CT images of the abdomen. (A) The CT revealed the right hydronephrosis and (B) a thickening of the right distal ureter (illustrated by the white arrow). CT, computed tomography.
See this image and copyright information in PMC

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