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. 1977 Nov;74(11):5051-5.
doi: 10.1073/pnas.74.11.5051.

Polypeptide hormone binding sites in vivo: initial localization of 125I-labeled insulin to hepatocyte plasmalemma as visualized by electron microscope radioautography

J J Bergeron, G Levine, R Sikstrom, D O'Shaughnessy, B Kopriwa, N J Nadler, B I Posner

Polypeptide hormone binding sites in vivo: initial localization of 125I-labeled insulin to hepatocyte plasmalemma as visualized by electron microscope radioautography

J J Bergeron et al. Proc Natl Acad Sci U S A. 1977 Nov.

Abstract

The rationale of the specific-binding assay was applied to the detection of the liver insulin receptor in vivo. Quantitative electron microscope radioautography indicated that, 3 min after an intraportal injection, 125I-insulin was exclusively located to the hepatocyte plasmalemma.

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