[The action of anaprilin and ketamine on fatty acid metabolism in the myocardium]

Abstract

The effects of anapriline, ketamine and anapriline administered during ketamine-induced anesthesia on contents of lipid fractions and ATP in the heart and on oxidation of fatty acids by myocardial mytochondria were studied on 200 albino rats. Administration of ketamine in a dose of 50 mg/kg induced blockade of lipolysis and a decrease of ATP content in the heart. At oxidation of fatty acids a decrease of respiratory control due to an increase of the rate of controlled mitochondrial respiration was noted. Anapriline (1 mg/kg) induced lipolysis blockade and ATP accumulation in the myocardium. Fatty acid oxidation was followed by activation of all rates of mitochondrial respiration and an increase of phosphorylation efficiency coefficient. Anapriline administered during ketamine-induced anesthesia prevented an impairment of myocardial bioenergy developing under the influence of ketamine that manifested itself in an increase of phosphorylating respiration rate, phosphorylation efficiency coefficient and ATP content in the myocardium.