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Review
. 2016 Dec;3(1):15.
doi: 10.1186/s40348-016-0043-9. Epub 2016 Apr 13.

Can the preterm lung recover from perinatal stress?

Matthias C Hütten  1   2   3   4 , Tim G A M Wolfs  1   4 , Boris W Kramer  5   6
Affiliations
Review

Can the preterm lung recover from perinatal stress?

Matthias C Hütten et al. Mol Cell Pediatr. 2016 Dec.

Abstract

After birth, adequate lung function is necessary for the successful adaptation of a preterm baby. Both prenatal and postnatal insults and therapeutic interventions have an immediate effect on lung function and gas exchange but also interfere with fetal and neonatal lung development. Prenatal insults like chorioamnionitis and prenatal interventions like maternal glucocorticosteroids interact but might also determine the preterm baby's lung response to postnatal interventions ("second hit") like supplementation of oxygen and drug therapy. We review current experimental and clinical findings on the influence of different perinatal factors on preterm lung development and discuss how well-established interventions in neonatal care might be adapted to attenuate postnatal lung injury.

Keywords: Bronchopulmonary dysplasia; Caffeine; Chorioamnionitis; Glucocorticosteroids; Lung injury; Oxygen toxicity; Ventilation; Vitamin A.

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Figures

Fig. 1
Fig. 1
Multiple factors influence lung development in preterm infants. Postnatally, both potentially protective and injurious factors are mainly associated with therapeutic means. IUGR intra-uterine growth restriction, PPROM preterm premature rupture of membranes, PIP positive inspiratory pressure, PEEP positive end-expiratory pressure, PDA persistent ductus arteriosus, NICU neonatal intensive care unit, BPD bronchopulmonary dysplasia
See this image and copyright information in PMC

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