The Human Vaccines Project: A roadmap for cancer vaccine development

Pedro Romero¹, Jacques Banchereau², Nina Bhardwaj³, Mark Cockett⁴, Mary L Disis⁵, Glenn Dranoff⁶, Eli Gilboa⁷, Scott A Hammond⁸, Robert Hershberg⁹, Alan J Korman¹⁰, Pia Kvistborg¹¹, Cornelis Melief¹², Ira Mellman¹³, A Karolina Palucka¹⁴, Irina Redchenko¹⁵, Harlan Robins¹⁶, Federica Sallusto¹⁷, Theodore Schenkelberg¹⁸, Stephen Schoenberger¹⁹, Jeffrey Sosman²⁰, Özlem Türeci²¹, Benoît Van den Eynde²², Wayne Koff²³, George Coukos²⁴

Affiliations

¹ Ludwig Cancer Research at University of Lausanne, 1066 Epalinges, Switzerland.
² The Jackson Laboratory for Genomic Medicine, Farmington, CT 06032, USA.
³ Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.
⁴ Bristol-Myers Squibb, Wallingford, CT06492, USA.
⁵ University of Washington School of Medicine, Seattle, WA 98109-4714, USA.
⁶ Novartis Institutes for Biomedical Research, Cambridge, MA 02139, USA.
⁷ Sylvester Comprehensive Cancer Center, Miami, FL 33136, USA.
⁸ MedImmune, Gaithersburg, MD 20878, USA.
⁹ Celgene Immuno-Oncology Center of Excellence, 1616 Eastlake Avenue, Suite 500, Seattle, WA 98102, USA.
¹⁰ Bristol-Myers Squibb, Biologics Discovery California, Redwood City, CA 94063, USA.
¹¹ Netherlands Cancer Institute, 1066CX Amsterdam, Netherlands.
¹² ISA Pharmaceuticals & Leiden University Medical Center, 2333 ZA Leiden, Netherlands.
¹³ Genentech, San Francisco, CA 94080, USA.
¹⁴ The Jackson Laboratory for Genomic Medicine, Farmington, CT 06032, USA. Baylor Institute for Immunology Research, Dallas, TX 75204, USA.
¹⁵ Oxford University, Oxford OX3 7DQ, UK.
¹⁶ Adaptive Biotechnologies, Fred Hutchinson Cancer Research Center, Seattle, WA 98102, USA.
¹⁷ Institute for Research in Biomedicine, Università della Svizzera italiana, 6500 Bellinzona, Switzerland.
¹⁸ West Monument Consulting, 1906 R Street NW Street 11, Washington, DC 20009, USA.
¹⁹ Center for Personalized Cancer Immunotherapy, La Jolla Institute for Allergy and Immunology & UCSD Moores Cancer Center, La Jolla, San Diego, CA 92037, USA.
²⁰ Vanderbilt University Medical Center and Vanderbilt Ingram Cancer Center, Nashville, TN 37232, USA.
²¹ CI3 Cluster for Individualized Immunotherapy, Kupferbergterasse 17-19, 55131 Mainz, Germany.
²² Ludwig Institute for Cancer Research, Brussels branch, Brussels, BRU 1200, Belgium. Université Catholique de Louvain, Avenue Hippocrate 10, 1200 Woluwe-Saint-Lambert, Belgium. University of Oxford, Nuffield Department of Medicine, Ludwig Institute for Cancer Research, Old Road Campus Research Building, Oxford OX3 7DQ, UK.
²³ International AIDS Vaccines Initiative, 125 Broad Street, 9th Floor, New York, NY 10004, USA.
²⁴ Ludwig Cancer Research at University of Lausanne, 1066 Epalinges, Switzerland. george.coukos@chuv.ch.

PMID: 27075624
DOI: 10.1126/scitranslmed.aaf0685

Review

The Human Vaccines Project: A roadmap for cancer vaccine development

Pedro Romero et al. Sci Transl Med. 2016.

. 2016 Apr 13;8(334):334ps9.

doi: 10.1126/scitranslmed.aaf0685.

Authors

Affiliations

¹ Ludwig Cancer Research at University of Lausanne, 1066 Epalinges, Switzerland.
² The Jackson Laboratory for Genomic Medicine, Farmington, CT 06032, USA.
³ Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.
⁴ Bristol-Myers Squibb, Wallingford, CT06492, USA.
⁵ University of Washington School of Medicine, Seattle, WA 98109-4714, USA.
⁶ Novartis Institutes for Biomedical Research, Cambridge, MA 02139, USA.
⁷ Sylvester Comprehensive Cancer Center, Miami, FL 33136, USA.
⁸ MedImmune, Gaithersburg, MD 20878, USA.
⁹ Celgene Immuno-Oncology Center of Excellence, 1616 Eastlake Avenue, Suite 500, Seattle, WA 98102, USA.
¹⁰ Bristol-Myers Squibb, Biologics Discovery California, Redwood City, CA 94063, USA.
¹¹ Netherlands Cancer Institute, 1066CX Amsterdam, Netherlands.
¹² ISA Pharmaceuticals & Leiden University Medical Center, 2333 ZA Leiden, Netherlands.
¹³ Genentech, San Francisco, CA 94080, USA.
¹⁴ The Jackson Laboratory for Genomic Medicine, Farmington, CT 06032, USA. Baylor Institute for Immunology Research, Dallas, TX 75204, USA.
¹⁵ Oxford University, Oxford OX3 7DQ, UK.
¹⁶ Adaptive Biotechnologies, Fred Hutchinson Cancer Research Center, Seattle, WA 98102, USA.
¹⁷ Institute for Research in Biomedicine, Università della Svizzera italiana, 6500 Bellinzona, Switzerland.
¹⁸ West Monument Consulting, 1906 R Street NW Street 11, Washington, DC 20009, USA.
¹⁹ Center for Personalized Cancer Immunotherapy, La Jolla Institute for Allergy and Immunology & UCSD Moores Cancer Center, La Jolla, San Diego, CA 92037, USA.
²⁰ Vanderbilt University Medical Center and Vanderbilt Ingram Cancer Center, Nashville, TN 37232, USA.
²¹ CI3 Cluster for Individualized Immunotherapy, Kupferbergterasse 17-19, 55131 Mainz, Germany.
²² Ludwig Institute for Cancer Research, Brussels branch, Brussels, BRU 1200, Belgium. Université Catholique de Louvain, Avenue Hippocrate 10, 1200 Woluwe-Saint-Lambert, Belgium. University of Oxford, Nuffield Department of Medicine, Ludwig Institute for Cancer Research, Old Road Campus Research Building, Oxford OX3 7DQ, UK.
²³ International AIDS Vaccines Initiative, 125 Broad Street, 9th Floor, New York, NY 10004, USA.
²⁴ Ludwig Cancer Research at University of Lausanne, 1066 Epalinges, Switzerland. george.coukos@chuv.ch.

PMID: 27075624
DOI: 10.1126/scitranslmed.aaf0685

Abstract

Cancer vaccine development has been vigorously pursued for 40 years. Immunity to tumor antigens can be elicited by most vaccines tested, but their clinical efficacy remains modest. We argue that a concerted international effort is necessary to understand the human antitumor immune response and achieve clinically effective cancer vaccines.

PubMed Disclaimer

Publication types

Actions
Actions

MeSH terms

Actions
Actions
Actions
Actions
Actions

Substances

Actions
Actions

Grants and funding

R01 AI107010/AI/NIAID NIH HHS/United States

LinkOut - more resources

Full Text Sources
- Atypon
Other Literature Sources
- The Lens - Patent Citations Database
- scite Smart Citations

Save citation to file

Email citation

Add to Collections

Add to My Bibliography

Your saved search

Create a file for external citation management software

Your RSS Feed

The Human Vaccines Project: A roadmap for cancer vaccine development

Affiliations

The Human Vaccines Project: A roadmap for cancer vaccine development

Authors

Affiliations

Abstract

Publication types

MeSH terms

Substances

Grants and funding

LinkOut - more resources

Full Text Sources

Other Literature Sources