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Review
. 2016 Feb;71(1):19-25.
doi: 10.1080/17843286.2015.1122871. Epub 2016 Feb 7.

Flow-assisted basophil activation tests in immediate drug hypersensitivity: two decades of Antwerp experience

E A Mangodt  1 , A L Van Gasse  1 , A Bastiaensen  1 , I I Decuyper  1 , A Uyttebroek  1 , M Faber  1 , V Sabato  1 , C H Bridts  1 , M M Hagendorens  2 , L S De Clerck  1 , D G Ebo  1
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Review

Flow-assisted basophil activation tests in immediate drug hypersensitivity: two decades of Antwerp experience

E A Mangodt et al. Acta Clin Belg. 2016 Feb.

Abstract

The last two decades have witnessed that flow-assisted analysis of in vitro-activated basophils can constitute a valuable adjunct in the in vitro diagnostic approach of immediate drug hypersensitivity reactions (IDHR). This article summarises the current experience with the basophil activation test in the diagnosis of IDHR, with particular focus on allergy to curarising neuromuscular blocking agents, antibiotics (β-lactams and fluoroquinolones), iodinated radiocontrast media and opiates.

Keywords: Allergy; Antibiotics; Basophil activation test (BAT), drug; CD203c; CD63; Curares; HistaFlow; Immediate drug hypersensitivity reaction (IDHR); Opiates.

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