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. 2016 Jul;71(7):2010-3.
doi: 10.1093/jac/dkw062. Epub 2016 Apr 13.

High incidence of neutropenia in patients with prolonged ceftaroline exposure

Kari J Furtek  1 , David W Kubiak  2 , Megan Barra  2 , Christy A Varughese  3 , Cameron D Ashbaugh  4 , Sophia Koo  4
Affiliations

High incidence of neutropenia in patients with prolonged ceftaroline exposure

Kari J Furtek et al. J Antimicrob Chemother. 2016 Jul.

Abstract

Objectives: We sought to determine the rate of incident neutropenia and identify potential clinical factors associated with incident neutropenia among patients treated with long courses of ceftaroline.

Methods: We retrospectively identified adult patients who received ceftaroline for ≥7 days consecutively at two large academic medical centres in Boston, USA between November 2010 and March 2015. Clinical characteristics (age, gender, medication allergies, baseline renal function, duration of ceftaroline exposure, total daily ceftaroline dose, body mass-adjusted ceftaroline dose and development of rash and neutropenia) were recorded and the rate of incident neutropenia was calculated. The Naranjo probability scale was used to assess whether ceftaroline exposure was associated with neutropenia. We assessed whether clinical factors were associated with neutropenia.

Results: The overall rate of incident neutropenia was 10%-14% with ≥2 weeks and 21% with ≥3 weeks of ceftaroline exposure. The median duration of ceftaroline exposure [26 days (IQR 22-44; range 13-68) in patients who developed neutropenia and 15 days (IQR 9-29; range 7-64) in patients without neutropenia] was associated with incident neutropenia (P = 0.048). The median total number of ceftaroline doses received [63 (IQR 44-126; range 36-198) by neutropenic patients and 32 (IQR 22-63; range 14-180) by non-neutropenic patients] was also associated with incident neutropenia (P = 0.023).

Conclusions: The overall rate of neutropenia was high and associated with duration of ceftaroline exposure and total number of doses received. Close laboratory monitoring is warranted with long-term ceftaroline use.

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Figures

Figure 1.
Figure 1.
WBC count (×103/mm3) and ANC (cells/mm3) trends of each patient with ceftaroline-associated neutropenia. GCSF, granulocyte colony-stimulating factor.
See this image and copyright information in PMC

References

    1. Teflaro (Ceftaroline Fosamil) Prescribing Information. St Louis: Forest Pharmaceuticals, October 2010. Revised May 2013.
    1. Paladino JA, Jacobs DM, Shields RK et al. . Use of ceftaroline after glycopeptides failure to eradicate methicillin-resistant Staphylococcus aureus bacteraemia with elevated vancomycin minimum inhibitory concentrations. Int J Antimicrob Agents 2014; 44: 557–63. - PubMed
    1. Lin JC, Aung G, Thomas A et al. . The use of ceftaroline fosamil in methicillin-resistant Staphylococcus aureus endocarditis and deep-seated MRSA infections: a retrospective case series of 10 patients. J Infect Chemother 2013; 19: 42–9. - PubMed
    1. Ho TT, Cadena J, Childs LM et al. . Methicillin-resistant Staphylococcus aureus bacteraemia and endocarditis treated with ceftaroline salvage therapy. J Antimicrob Chemother 2012; 67: 1267–70. - PubMed
    1. Rimawi RH, Frenkel A, Cook PP. Ceftaroline—a cause for neutropenia . J Clin Pharm Ther 2013; 38: 330–2. - PubMed

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