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. 2016 Apr;110(4):219-27.
doi: 10.1093/trstmh/trw017.

Diabetes mellitus and impaired fasting glucose in ART-naïve patients with HIV-1, HIV-2 and HIV-1/2 dual infection in Guinea-Bissau: a cross-sectional study

Ditte Steiniche  1 , Sanne Jespersen  2 , Christian Erikstrup  3 , Henrik Krarup  4 , Aase Handberg  5 , Lars Østergaard  6 , Thorny Haraldsdottir  7 , Candida Medina  8 , Faustino Gomes Correira  8 , Alex Lund Laursen  6 , Morten Bjerregaard-Andersen  9 , Christian Wejse  10 , Bo Langhoff Hønge  11 ; Bissau HIV Cohort study group
Collaborators, Affiliations

Diabetes mellitus and impaired fasting glucose in ART-naïve patients with HIV-1, HIV-2 and HIV-1/2 dual infection in Guinea-Bissau: a cross-sectional study

Ditte Steiniche et al. Trans R Soc Trop Med Hyg. 2016 Apr.

Abstract

Background: The prevalence of diabetes mellitus (DM) is expected to increase in sub-Saharan Africa. Patients with HIV are at particular risk. We investigated the DM burden among antiretroviral therapy (ART)-naïve patients with HIV in Guinea-Bissau.

Methods: Patients were consecutively included. Demographic and lifestyle data were collected and one fasting blood glucose (FBG) measurement was used to diagnose DM (FBG≥7.0 mmol/L) and impaired fasting glucose (IFG) (FBG≥6.1 and <7.0 mmol/L).

Results: By June 2015, 953 newly diagnosed ART-naïve patients with HIV had been included in the study of whom 893 (93.7%) were fasting at the time of inclusion. Median age among the fasting patients was 37 years (IQR 30-46 years) and 562 (62.9%) were women. The prevalence of DM was 5.8% (52/893) while 5.6% (50/893) had IFG. DM was associated with family history of DM (OR 3.92, 95% CI 1.78 to 8.63), being 41-50 years (OR 2.98, 95% CI 1.18 to 7.49) or older than 50 years (OR 3.14, 95% CI 1.09 to 9.07) and Fula ethnicity (OR 2.72, 95% CI 1.12 to 6.62).

Conclusions: DM prevalence was higher among younger patients compared with the background population in Bissau. Traditional risk factors for DM such as advancing age and a family history of DM apply also for ART-naïve patients with HIV.

Keywords: Diabetes mellitus; Guinea-Bissau; HIV; Impaired fasting glucose.

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Figures

Figure 1.
Figure 1.
Flowchart of enrolment. ART: antiretroviral treatment; DM: diabetes mellitus; FBG: fasting blood glucose; IFG: impaired fasting glucose.
See this image and copyright information in PMC

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