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. 2016 Apr;110(4):258-60.
doi: 10.1093/trstmh/trw014.

Transmission of Plasmodium vivax in Duffy-negative individuals in central Sudan

Mohamed H Abdelraheem  1 , Musab M A Albsheer  2 , Hiba S Mohamed  2 , Mutaz Amin  3 , Muzamil Mahdi Abdel Hamid  4
Affiliations

Transmission of Plasmodium vivax in Duffy-negative individuals in central Sudan

Mohamed H Abdelraheem et al. Trans R Soc Trop Med Hyg. 2016 Apr.

Abstract

Background: Due to the recently observed rise in Plasmodium vivax incidence in Sudan and reported transmission in Duffy-negative individuals; we aimed to assess the possibility of P. vivax transmission in Duffy-negative individuals in Gezira state, central Sudan.

Method: A total of 126 suspected malaria patients were diagnosed with P. vivax infection using microscopy, RDT and PCR. PCR-RFLP was used to genotype participants Duffy status.

Results: Forty eight (38%) were positive for P. vivax infection by PCR. Four patients (8.3%) were homozygous Duffy-negative.

Conclusion: These results confirm that P. vivax can infect Duffy-negative individuals, suggesting alternative mechanisms to bind and invade erythrocytes.

Keywords: Duffy antigen receptor; Gezira; Malaria; PCR; Plasmodium vivax; Sudan.

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