Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2016 Mar-Apr;13(2):151-9.
doi: 10.4103/1735-3327.178202.

A randomized controlled evaluation of alveolar ridge preservation following tooth extraction using deproteinized bovine bone mineral and demineralized freeze-dried bone allograft

Rokhsareh Sadeghi  1 , Maryam Babaei  2 , S Asghar Miremadi  3 , Fatemeh Mashadi Abbas  4
Affiliations

A randomized controlled evaluation of alveolar ridge preservation following tooth extraction using deproteinized bovine bone mineral and demineralized freeze-dried bone allograft

Rokhsareh Sadeghi et al. Dent Res J (Isfahan). 2016 Mar-Apr.

Abstract

Background: Alveolar ridge preservation could be performed immediately following tooth extraction to limit dimensional changes of alveolar process due to bone resorption. The aim of this study was to compare the clinical and histologic outcomes of socket preservation using two different graft materials; deproteinized bovine bone mineral (DBBM) and demineralized freeze-dried bone allograft (DFDBA) with absorbable collagen membrane.

Materials and methods: Twenty extraction sockets in 20 patients were randomly divided into 2 treatment groups: 10 sockets were augmented with DBBM and collagen membrane whereas 10 sockets were filled with DFDBA and covered by collagen membrane. Primary closure was achieved over extraction sockets by flap advancement. Horizontal and vertical ridge dimensional changes were assessed at baseline and after 4-6 months at the time of implant placement. For histological and histomorphometrical analysis, bone samples were harvested from the augmented sites with trephine during implant surgery. All data were analyzed using SPSS version 18 (α=0.05).

Results: Clinical measurements revealed that average horizontal reduction was 2.3 ± 0.64 mm for DFDBA and 2.26 ± 0.51 mm for DBBM. Mean vertical ridge resorption at buccal side was 1.29 ± 0.68 mm for DFDBA and 1.1 ± 0.17 mm for DBBM. Moreover, mean vertical ridge reduction at lingual site was 0.41 ± 0.38 mm and 0.35 ± 0.34 mm for DFDBA and DBBM, respectively. No significant differences were seen between two groups in any of those clinical parameters. Histologic analysis showed statistically significant more new bone deposition for DFDBA compared to DBBM (34.49 ± 3.19 vs. 18.76 ± 3.54) (P < 0.01). Residual graft particles were identified significantly more in DBBM (12.77 ± 1.85) than DFDBA (6.06 ± 1.02).

Conclusion: Based on the findings of this study, both materials have positive effect on alveolar ridge preservation after tooth extraction, but there was more new bone formation and less residual graft particles in DFDBA group than in DBBM group.

Keywords: Collagen; extraction; graft; material; membrane; preservation; socket.

PubMed Disclaimer

Figures

Figure 1
Figure 1
Occlusal view after atraumatic extraction of canine tooth. The socket was debrided with curette to remove all granulation tissues and periradicular lesion.
Figure 2
Figure 2
Vertical measurements with acrylic stent in place.
Figure 3
Figure 3
Horizontal measurement.
Figure 4
Figure 4
The socket was grafted with demineralized freeze-dried bone allograft and trimmed collagen membrane covered the socket and buccal bone.
Figure 5
Figure 5
Section from a deproteinized bovine bone mineral site specimen. Newly formed bone (NB) and residual graft particles (GP) were present (×40).
Figure 6
Figure 6
Section from a demineralized freeze-dried bone allograft site specimen. Newly formed bone (NB) and residual graft particles (GP) were present (×40).
Figure 7
Figure 7
Calcifying osteoid (O) in close contact with residual graft particles (GP) of deproteinized bovine bone mineral (×400).
Figure 8
Figure 8
Residual graft particles (GP) of demineralized freeze-dried bone allograft in the proximity of the fatty vascular connective tissue (×400).
See this image and copyright information in PMC

References

    1. Lekovic V, Kenney EB, Weinlaender M, Han T, Klokkevold P, Nedic M, et al. A bone regenerative approach to alveolar ridge maintenance following tooth extraction. Report of 10 cases. J Periodontol. 1997;68:563–70. - PubMed
    1. Lekovic V, Camargo PM, Klokkevold PR, Weinlaender M, Kenney EB, Dimitrijevic B, et al. Preservation of alveolar bone in extraction sockets using bioabsorbable membranes. J Periodontol. 1998;69:1044–9. - PubMed
    1. Iasella JM, Greenwell H, Miller RL, Hill M, Drisko C, Bohra AA, et al. Ridge preservation with freeze-dried bone allograft and a collagen membrane compared to extraction alone for implant site development: A clinical and histologic study in humans. J Periodontol. 2003;74:990–9. - PubMed
    1. Sobolik CF. Alveolar bone resorption. J Prosthet Dent. 1960;10:612–9.
    1. Garg AK. Alveolar ridge preservation during and after surgical tooth removal. Interview. Dent Implantol Update. 2001;12:57–62. - PubMed

LinkOut - more resources